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Intrafractional motion models based on principal components in Magnetic Resonance guided prostate radiotherapy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology. Department of Medical Physics, Akademiska Hospital, Uppsala, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Department of Medical Physics, Akademiska Hospital, Uppsala, Sweden;Elekta Instruments AB, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
Department of Radiation Sciences, Umeå University, Umeå, Sweden.
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2021 (English)In: Physics and Imaging in Radiation Oncology, E-ISSN 2405-6316, Vol. 20, p. 17-22Article in journal (Refereed) Published
Abstract [en]

Background and purpose:

Devices that combine an MR-scanner with a Linac for radiotherapy, referred to as MR-Linac systems, introduce the possibility to acquire high resolution images prior and during treatment. Hence, there is a possibility to acquire individualised learning sets for motion models for each fraction and the construction of intrafractional motion models. We investigated the feasibility for a principal component analysis (PCA) based, intrafractional motion model of the male pelvic region.

Materials and methods:

4D-scans of nine healthy male volunteers were utilized, FOV covering the entire pelvic region including prostate, bladder and rectum with manual segmentation of each organ at each time frame. Deformable image registration with an optical flow algorithm was performed for each subject with the first time frame as reference. PCA was performed on a subset of the resulting displacement vector fields to construct individualised motion models evaluated on the remaining fields.

Results:

The registration algorithm produced accurate registration result, in general DICE overlap >0.95 across all time frames. Cumulative variance of the eigen values from the PCA showed that 50% or more of the motion is explained in the first component for all subjects. However, the size and direction for the components differed between subjects. Adding more than two components did not improve the accuracy significantly and the model was able to explain motion down to about 1 mm.ConclusionsAn individualised intrafractional male pelvic motion model is feasible. Geometric accuracy was about 1 mm based on 1–2 principal components.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 20, p. 17-22
Keywords [en]
Radiology Nuclear Medicine and imaging, Radiation
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-459335DOI: 10.1016/j.phro.2021.09.004ISI: 000730754800004PubMedID: 34660917OAI: oai:DiVA.org:uu-459335DiVA, id: diva2:1613566
Available from: 2021-11-22 Created: 2021-11-22 Last updated: 2024-05-16Bibliographically approved
In thesis
1. Machine Learning in Magnetic Resonance-Guided Adaptive Radiotherapy
Open this publication in new window or tab >>Machine Learning in Magnetic Resonance-Guided Adaptive Radiotherapy
2024 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In radiotherapy, treatments are frequently distributed over multiple weeks, and the radiation dose delivered across several sessions. A significant hurdle in this approach is the anatomical changes that occur between the planning stage and subsequent treatment sessions, leading to uncertainties in the treatment. The MR-Linac system, which combines a linear accelerator with an MRI scanner, addresses this issue by allowing for daily adjustments to the treatment plan based on the patient's current anatomy. However, the process for making these adjustments, involving image fusion, re-contouring, and plan re-optimization, can be quite elaborate and time-consuming. This project aimed to identify opportunities within the daily treatment routine where machine learning and deep learning could streamline the process, thereby enhancing efficiency, with a focus on prostate cancer treatments due to their frequent occurrence at our facility. We leveraged deep learning to train patient-specific models for segmenting anatomical structures in daily MRI scans, matching the accuracy of existing deformable image registration techniques. Furthermore, we extended this concept to segmenting structures and predicting radiation dose distributions, offering a swift assessment of potential dose distribution before engaging in the more complex manual workflow. This could aid in selecting the most suitable adaptation method more quickly. Additionally, we developed motion models for intrafractional motion and for segmenting images at lower resolutions to facilitate a target tracking process. Throughout this project, we showed how machine learning and deep learning techniques could contribute to optimizing the daily MR-Linac workflow.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2024. p. 55
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 2044
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
Medical Radiophysics
Identifiers
urn:nbn:se:uu:diva-526296 (URN)978-91-513-2114-1 (ISBN)
Public defence
2024-05-31, H:son Holmdahlsalen, Akademiska Sjukhuset, ing 100, Uppsala, 13:00 (English)
Opponent
Supervisors
Available from: 2024-05-06 Created: 2024-04-09 Last updated: 2024-05-16

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Fransson, SamuelTilly, DavidAhnesjö, AndersStrand, Robin

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