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Parameter Inference for Stochastic Models of Gene Expression in Eukaryotic Cells
Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
2023 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Simulation models are often used to study a system or phenomenon. However, before a simulation model can be used, its parameter needs to be fit to mimic observed data. This is called the parameter inference problem. This thesis approaches this problem for stochastic simulations using sequential Monte Carlo approximate Bayesian computation in conjunction with summary statistics trained by a convolutional neural network as the main method. Other approaches to solving this problem were also explored using traditional summary statistics with the aforementioned method and a completely different approach called simulation-based inference where a density estimator is trained. The approach using convolutional neural network-trained statistics showed promising results for two of the five explored data sets given by collaborators from the University of Edinburgh (Prof. Ramon Grima) and the Netherlands Cancer Institute (Prof. Tineke Lenstra). Further investigation is needed in order to enable accurate parameter inference for the other three datasets. 

Place, publisher, year, edition, pages
2023. , p. 36
Series
IT ; 23021
National Category
Computer Sciences
Identifiers
URN: urn:nbn:se:uu:diva-505583OAI: oai:DiVA.org:uu-505583DiVA, id: diva2:1771305
Educational program
Bachelor Programme in Computer Science
Supervisors
Examiners
Available from: 2023-06-20 Created: 2023-06-20 Last updated: 2023-06-20Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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More styles
Language
  • de-DE
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  • en-US
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  • nn-NB
  • sv-SE
  • Other locale
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Output format
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