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Assessment and psychological treatment of depression in older adults
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Centre for Clinical Research, County of Västmanland. Centre for Clinical Research, Uppsala University and County Hospital of Västerås, Sweden.ORCID iD: 0000-0002-0707-0832
2023 (English)Doctoral thesis, comprehensive summary (Other academic)
Description
Abstract [en]

Depression is one of the leading causes of disability in older adults worldwide. Many older adults with depression are undetected, and there is a need for brief, scalable psychological treatments for depression that can be delivered remotely.

The aims of this thesis were 1) to investigate the diagnostic accuracy of two rating scales (PHQ-9 and GDS-15) for the detection of depression in older adults, and 2) to investigate the feasibility, preliminary efficacy and patients’ experiences of a telephone-based psychological intervention, Behavioral activation with mental imagery (BA-MI), for the treatment of depression in older adults in the context of the covid-19 pandemic. 

Study I showed that a cutoff of ≥6 on the GDS-15 and ≥5 on the PHQ-9 were optimal to identify major depressive disorder. When identifying both major depressive disorder and subthreshold depression, the optimal cutoff on the GDS-15 was ≥5. Study II was a randomized clinical pilot trial, CoviDep, with a treatment group receiving the BA-MI intervention, and a control group. The drop-out rate was low. Compared to the control group, the treatment group reported a decrease in depressive symptoms throughout the treatment, with a large effect-size at posttreatment. Study III was a long-term follow-up of participants in CoviDep that received the BA-MI intervention. The drop-out rate over time was low, and compared to baseline, decreases in depressive symptoms were observed with a medium effect-size at posttreatment that was maintained 1- and 3 months post-treatment but lower after 6 months. Study IV was a qualitative study. The BA-MI intervention in CoviDep was described as increasing activities and improving mood. Telephone-delivery reduced barriers due to pandemic restrictions but felt less personal and lacking non-verbal communication. Being recognized and talking to a therapist every week was healing, but the manualized mode of treatment seemed to impair the relationship.

In sum, this thesis shows that both the GDS-15 and the PHQ-9 are useful tools for the detection of depression in older adults, and adds to the support for telephone-delivered BA for the treatment of depression and indicates that MI-interventions are feasible as an augmentation of BA in older adults.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2023. , p. 82
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1984
Keywords [en]
Aging, geriatric, late life, cbt, screening
National Category
Geriatrics General Practice Psychiatry
Research subject
Family Medicine; Geriatrics; Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-514227ISBN: 978-91-513-1928-5 (print)OAI: oai:DiVA.org:uu-514227DiVA, id: diva2:1804955
Public defence
2023-12-01, Samlingssalen, Psykiatricentrum, ingång 29, Västmanlands sjukhus, Västerås, 13:15 (Swedish)
Opponent
Supervisors
Available from: 2023-11-10 Created: 2023-10-14 Last updated: 2023-11-10
List of papers
1. Accuracy in detecting major depressive episodes in older adults using the Swedish versions of the GDS-15 and PHQ-9
Open this publication in new window or tab >>Accuracy in detecting major depressive episodes in older adults using the Swedish versions of the GDS-15 and PHQ-9
2021 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 126, no 1, article id e7848Article in journal (Refereed) Published
Abstract [en]

Objectives: The purpose of this study was to evaluate the diagnostic accuracy at different cut-off values for the Swedish versions of the 15-item Geriatric Depression Scale (GDS-15) and Patient Health Questionnaire (PHQ-9) compared with a structured clinical psychiatric interview in older adults.

Methods: Community-dwelling participants (N = 113) aged 65 years or older completed the Swedish versions of the GDS-15 and PHQ-9 and were then interviewed using the Mini International Neuropsychiatric Interview (MINI) to establish the presence or absence of current major depressive episodes (MDEs). Areas under the curve (AUC) were calculated for each scale, as well as the sensitivity, specificity, and Youden's index for different cut-off values.

Results: Seventeen participants met the criteria for MDEs. The AUC was 0.97 for the GDS-15 and 0.95 for the PHQ-9. A cut-off of >= 6 on the GDS-15 yielded a sensitivity of 94%, a specificity of 88%, and a Youden's index of 0.82. A cut-off of >= 5 on the PHQ-9 yielded a sensitivity of 100%, a specificity of 81%, and a Youden's index of 0.81. The proposed cut-off of >= 10 on the PHQ-9 produced excellent specificity of 95% but a lower sensitivity of 71%.

Conclusions: This study indicates that the Swedish versions of the GDS-15 and PHQ-9 have comparable accuracy as screening instruments for older adults with MDEs. However, the proposed cut-off of 10 on the PHQ-9 might be too high when applied to older individuals in Sweden, and further investigations in larger samples in different healthcare settings are warranted.

Place, publisher, year, edition, pages
Upsala Medical SocietyUppsala Medical Society, 2021
Keywords
Depression, geriatric, validation, screening, rating scales
National Category
Applied Psychology
Identifiers
urn:nbn:se:uu:diva-459768 (URN)10.48101/ujms.v126.7848 (DOI)000714582400001 ()34754407 (PubMedID)
Funder
Region Västmanland
Available from: 2021-11-30 Created: 2021-11-30 Last updated: 2024-01-15Bibliographically approved
2. Telephone-based behavioral activation with mental imagery for depression: A pilot randomized clinical trial in isolated older adults during the Covid-19 pandemic
Open this publication in new window or tab >>Telephone-based behavioral activation with mental imagery for depression: A pilot randomized clinical trial in isolated older adults during the Covid-19 pandemic
2022 (English)In: International Journal of Geriatric Psychiatry, ISSN 0885-6230, E-ISSN 1099-1166, Vol. 37, no 1Article in journal (Refereed) Published
Abstract [en]

Objectives

To shield vulnerable persons, particularly the elderly, during the Covid-19 pandemic governments around the world have advised to use social distancing and self-isolation. Social isolation might put older adults at an increased risk for mental health problems such as depression. There is a need for brief, easy-accessible psychological treatments for depressive symptoms that can be delivered remotely. The aim of this study was to investigate the feasibility, acceptability, and preliminary efficacy of telephone-delivered Behavioral Activation with Mental Imagery (BA-MI) for the treatment of depressive symptoms in individuals 65 years and older living in isolation during the Covid-19 pandemic.

Methods

In this open-label pilot randomized clinical trial, N = 41 individuals aged 65 years or older with clinically significant symptoms of depression were randomly assigned to either a BA-MI treatment condition, or an Attention-Assessment control condition delivered over the telephone over a 4-week period.

Results

Depressive symptoms decreased more in the treatment condition compared to the control condition. At post-treatment, 2 out of 16 participants in the treatment condition met diagnostic criteria for depression compared to 9 out of 13 in the control condition. Most participants in the treatment condition were satisfied with the treatment and few adverse effects were observed.

Conclusions

This pilot study suggests that behavioral activation with mental imagery delivered over the telephone is feasible, acceptable, and potentially efficacious for the treatment of depressive symptoms in older individuals living in isolation. Replication in larger samples is needed.

Place, publisher, year, edition, pages
John Wiley & SonsWiley, 2022
Keywords
activity scheduling, behavioral activation, depression, mental imagery, older adults, social isolation
National Category
Psychiatry
Identifiers
urn:nbn:se:uu:diva-464080 (URN)10.1002/gps.5646 (DOI)000716909900001 ()34729823 (PubMedID)
Funder
Region Västmanland
Available from: 2022-01-13 Created: 2022-01-13 Last updated: 2024-01-15Bibliographically approved
3. Telephone-Based Behavioral Activation with Mental Imagery for Depression in Older Adults in Isolation During the covid-19 Pandemic: Long-term Results from a Pilot Trial
Open this publication in new window or tab >>Telephone-Based Behavioral Activation with Mental Imagery for Depression in Older Adults in Isolation During the covid-19 Pandemic: Long-term Results from a Pilot Trial
2023 (English)In: Clinical Gerontologist, ISSN 0731-7115, E-ISSN 1545-2301, Vol. 46, no 5, p. 801-807Article in journal (Refereed) Published
Abstract [en]

Objectives: The covid-19 pandemic has highlighted the need for psychological interventions for depression that can be delivered remotely to older adults. Pellas et al. (2022) conducted a pilot trial on the preliminary effectiveness of a four-week telephone-delivered Behavioral Activation with Mental Imagery (BA-MI) intervention to N= 38 adults 65 years and older with clinically significant depressive symptoms living in isolation due to covid-19 in Sweden. This study assessed the feasibility of follow-up assessments and within-group symptom change over a six-month post-intervention period.

Methods: Retention rates at post-intervention and follow-up assessments of depressive symptoms (MADRS-S) at five time points were assessed (baseline, post-intervention, 1-, 3-, and 6-month follow- up). Effect sizes (Hedges' g) for within-group change scores were calculated between each time point.

Results: Retention rates over time were 95, 82, 89, and 84%. Mean MADRS-S score was 18.26 at baseline, 13.69 at post-intervention (g= .68), 13.42 at 1 month (g= .74), 13.82 at 3 months (g= .74), and 15.59 at 6 months (g= .41).

Conclusions: Long-term follow-ups were feasible. Within-group decreases in depressive symptoms were maintained with medium effect sizes at 6 months post-intervention.

Clinical implications: Telephone-based BA-MI may be a feasible intervention for depressive symptoms in older adults in isolation with maintained effects over time.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2023
Keywords
Aging, elderly, cbt, geriatric
National Category
Psychiatry Applied Psychology
Research subject
Psychology; Psychiatry
Identifiers
urn:nbn:se:uu:diva-485745 (URN)10.1080/07317115.2022.2124899 (DOI)000856090400001 ()36128612 (PubMedID)
Funder
Region Västmanland, LTV-938621
Available from: 2022-09-27 Created: 2022-09-27 Last updated: 2024-07-02Bibliographically approved
4. Not the same, but similar: a qualitative study of older adults’ experiences of a telephone-based psychological treatment for depression during the covid-19 pandemic
Open this publication in new window or tab >>Not the same, but similar: a qualitative study of older adults’ experiences of a telephone-based psychological treatment for depression during the covid-19 pandemic
Show others...
(English)Manuscript (preprint) (Other academic)
Abstract [en]

Objectives: The covid-19 pandemic prompted the use of telehealth interventions for treating depression in older adults. We conducted a pilot study of a telephone-based brief psychological intervention, Behavioral Activation with Mental Imagery (BA-MI), for the treatment of depression in isolated older adults during the covid-19 pandemic. The results showed promising results regarding satisfaction and reduction in depressive symptoms. The purpose of the present study was to investigate the participants’ experiences of the intervention and provide insight into how the intervention could be improved. 

Methods: Fourteen participants from the pilot study, aged 67 – 85 years, were purposively selected and interviewed. The interviews were analyzed using thematic analysis with a descriptive phenomenological approach. 

Results: The BA-MI intervention was experienced as a good way of increasing activities and improving mood. Telephone-delivery reduced barriers due to pandemic restrictions but felt less personal and lacking non-verbal communication. Being recognized and talking to a therapist every week was healing, but the manualized mode of treatment seemed to impair the relationship.

Conclusions: Telephone-based psychological treatment is similar to face-to-face treatment but not the same, with several advantages but also with shortcomings that should be considered by the clinician. When using manual-based psychological interventions one should aim to make them as person-centred as possible by making room for the patients as individuals with both past and present rather than just focusing on intervention delivery.

Keywords
Aging, elderly, cbt, geriatric, late life, qualitative
National Category
Psychiatry
Research subject
Psychiatry
Identifiers
urn:nbn:se:uu:diva-513935 (URN)
Funder
Region Västmanland
Available from: 2023-10-13 Created: 2023-10-13 Last updated: 2023-10-14

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