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Effects of telemonitoring follow-up, side effects, and other factors on CPAP adherence
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Centre for Clinical Research Sörmland. Department of Patient Safety, Region Sörmland, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.ORCID iD: 0000-0002-8552-4510
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics.ORCID iD: 0000-0002-4640-9149
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.ORCID iD: 0000-0001-7346-1674
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2023 (English)In: Journal of Clinical Sleep Medicine (JCSM), ISSN 1550-9389, E-ISSN 1550-9397, Vol. 19, no 10, p. 1785-1795Article in journal (Refereed) Published
Abstract [en]

Study objectives: This study aimed to investigate the effect of telemonitoring compared with standard clinic visits on adherence to continuous positive airway pressure (CPAP) treatment after 6 months. In addition, the impact of other factors including CPAP side effects on treatment adherence were assessed.

Methods: Consecutive patients (n = 217) who were prescribed CPAP treatment for obstructive sleep apnea were randomized to either telemonitoring or standard-care follow-up. All patients were followed up 6 months after treatment started. Clinical/anthropometric variables, socioeconomical and lifestyle factors, psychological distress, daily function, and personality traits along with CPAP side effects were assessed. Differences between groups were analyzed using 2-sample t-test, chi-square test, or Fisher's exact test. Regression modeling was used to explore associations between dependent and independent variables.

Results: There were no differences in CPAP adherence between telemonitoring and standard-care groups after 6 months (53.2% vs 48.7%; P = .54). CPAP side effects such as dry throat (odds ratio = 2.17; 95% confidence interval = 1.25-3.70), increased awakenings (2.50; 1.31-4.76), and exhaling problems (3.70; 1.25-10.1) were independently associated with low CPAP adherence, although these associations were weakened when adding smoking to the model. No other baseline or follow-up factors were associated with CPAP adherence at 6 months.

Conclusions: We could not show that telemonitoring follow-up improved adherence levels. Dry throat, increased awakenings, exhaling problems, and smoking had negative effects on CPAP adherence. Preventing side effects and assessing smoking status is therefore of importance when wanting to improve CPAP adherence.

Place, publisher, year, edition, pages
American Academy of Sleep Medicine , 2023. Vol. 19, no 10, p. 1785-1795
National Category
Other Basic Medicine
Research subject
Health Care Research
Identifiers
URN: urn:nbn:se:uu:diva-516698DOI: 10.5664/jcsm.10686ISI: 001091257000013PubMedID: 37323036OAI: oai:DiVA.org:uu-516698DiVA, id: diva2:1815595
Funder
Erik, Karin och Gösta Selanders FoundationAvailable from: 2023-11-29 Created: 2023-11-29 Last updated: 2025-09-03Bibliographically approved
In thesis
1. CPAP treatment adherence and head extension therapy by cervical collar in Obstructive sleep apnea
Open this publication in new window or tab >>CPAP treatment adherence and head extension therapy by cervical collar in Obstructive sleep apnea
2025 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Background:  Obstructive Sleep Apnea (OSA) causes repeated airway blockages during sleep, leading to low oxygen levels, poor sleep quality, and increased risk of cardiovascular disease and type 2 diabetes. Treatments such as mandibular advancement devices (MAD) or CPAP (Continuous Positive Airway Pressure), require high adherence, which is often lacking. As a result, many patients remain untreated, underscoring the need for new therapeutic alternatives.

Aims and Methods: Paper I: A randomised controlled study investigated the effect of telemedicine (TM) compared with standard clinic visits (SC) on adherence to CPAP treatment after 6 months. It also examined the impact of other factors, including CPAP side effects, on treatment adherence in 217 patients with OSA. 

Paper II: A randomised, open, parallel-group intervention study evaluated the effect of head extension using a cervical collar on the respiratory events index [(REI) i.e. apnea-hypopnea index (AHI)] in 100 patients with moderate OSA. The lifestyle intervention group (LS) received life-style advice only, while the cervical collar group (CC/LS) received both lifestyle advice and treatment with an adjustable cervical collar to promote head extension during sleep. Assessments, including questionnaires and polygraphy, were performed at baseline and after 6 ± 2 weeks.

Paper III: A qualitative study explored and highlighted patients’ experiences of cervical collar treatment for OSA in seven patients from the intervention group (CC/LS) of the previous randomised controlled trial (Paper II). Qualitative content analysis was performed in accordance with the method of Graneheim and Lundman.

Results and conclusions: There were no differences in CPAP adherence between the TM and SC groups after 6 months, suggesting that TM does not improve adherence to CPAP treatment over this period. Factors negatively affecting CPAP adherence included smoking and side effects such as dry throat, increased awakenings, and difficulty exhaling.

The patient group (CC/LS) showed a greater reduction in REI compared with the LS group. The reduction in REI was particularly pronounced in the supine position. Thus, a cervical collar may be a viable second-line treatment option for OSA, especially in cases of positional OSA. 

Patients found the cervical collar improved sleep and daytime alertness but noted it was bulky and required adjustment. Despite challenges, it is viewed as helpful and should be more widely available.

Place, publisher, year, edition, pages
Uppsala: Annat förlag, 2025. p. 78
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 2181
Keywords
Obstructive sleep apnea, Cervical collar, Continuous positive airway pressure (CPAP), CPAP adherence, Head extension, Head posture, Pa-tient experience, Telemedicine, Tele-monitoring, Upper airway
National Category
Respiratory Medicine and Allergy
Research subject
Medical Science
Identifiers
urn:nbn:se:uu:diva-566323 (URN)978-91-513-2597-2 (ISBN)
Public defence
2025-11-06, A1:107a, Biomedicinskt centrum (BMC), Uppsala, 09:00 (Swedish)
Opponent
Supervisors
Note

Tidpunkt för disputation korrigerad.

Available from: 2025-10-14 Created: 2025-09-03 Last updated: 2025-10-20

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