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Aim: There has been limited research about the associations between pre-eclampsiaand neonatal complications in relation to gestational age. This register-basedstudyaimed to address that gap in our knowledge.

Methods: We used Swedish Medical Birth Register to carry out a population-basedstudy on primiparas with singleton pregnancies from 1999 to 2017. Descriptivestatistics and logistic regressions were used to study the associations betweenpre-eclampsiaand neonatal complications in different gestational ages. The data ispresented as adjusted odds ratios (aORs) with 95% CI.

Results: The study comprised 805 591 primiparas: 2.9% had mild to moderate pre-eclampsiaand 1.4% had severe pre-eclampsia.Neonates born to women with pre-eclampsiahad increased risks of several complications compared to those born tomothers without pre-eclampsia.After adjustment for confounding variables, therisk of being small for gestational age (aOR 5.3, CI: 5.1–5.5) and needing resuscitation(aOR 2.6, CI: 2.4–2.7) were increased. The risk of a low Apgar score and convulsions/hypoxic ischemic encephalopathy was increased at 32–41 weeks of gestation.Moreover, the overall risk of sepsis (aOR 1.9. CI: 1.8–2.1) and perinatal death (aOR 1.2,CI: 1.1–1.5) was also increased.

Conclusion: Compared with infants of mothers without pre-eclampsia,those exposedto pre-eclampsiahad higher risks of all the studied neonatal complications.