To better understand the increasing human impact on the water cycle and the feedbacks between hydrology and society, the International Association of Hydrological Sciences (IAHS) organized the scientific decade “Panta Rhei – Everything Flows: Change in hydrology and society” (2013–2022). A key finding is the need to use integrated approaches to assess the co-evolution of human–water systems in order to avoid unintended consequences of human interventions over long periods of time. Additionally, substantial progress has been made in leveraging new data sources on human behaviour, e.g. through text mining of social media posts. Much has been learned about detecting hydrological changes and attributing them to their drivers, e.g. quantifying climate effects on floods. To achieve further progress, we recommend broadening the understanding, the discipline and training activities, while at the same time pursuing synthesis by focusing on key themes, developing innovative approaches and finding sustainable solutions to the world’s water problems.