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Exploring balance and balance assessment in patients with chronic pain: A behavioral medicine perspective
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Physiotherapy and behavioral medicine.ORCID iD: 0000-0002-1196-7810
2025 (English)Doctoral thesis, comprehensive summary (Other academic)
Description
Abstract [en]

Chronic pain (> 3 months) is associated with balance impairments and risk of falls. This thesis explored how well the Mini-BESTest captures dynamic balance in patients with chronic pain referred to specialized pain care, focusing on ecological validity and patient perspectives informed by behavioral medicine. It also examined how physical, psychosocial, pharmacological, and behavioral factors relate to dynamic balance and perceived challenges in everyday life.

Specific aims: Studies I–II evaluated the Mini-BESTest’s validity, reliability, and patients’ perspectives on balance. Study III examined patient characteristics and opioid-related factors associated with balance, and Study IV explored characteristics linked to long-term and prescription opioid use disorder (P-OUD).

Methods: All studies included patients with chronic pain referred to specialized pain care. Study I (n = 180) assessed construct validity, and Study II (n = 53 + 15) assessed test-retest reliability and explored perceptions of balance through qualitative interviews. Studies III (n = 179) and IV (n = 339) analyzed dynamic balance and opioid use in relation to biopsychosocial characteristics using regression models.

Results: Studies I and II supported the Mini-BESTest’s construct validity, internal consistency, and test-retest reliability, but did not fully reflect patients’ perceptions of balance in everyday life. In Study III, poorer dynamic balance was associated with oxycodone use, older age, lower education, low pain self-efficacy, and low physical activity. In Study IV, long-term opioid use was linked to longer pain duration, unemployment, more catastrophizing, lower quality of life, and worse dynamic balance. P-OUD was associated with younger age, trauma exposure, catastrophizing, and fear of movement, but not with balance.

Conclusion: The Mini-BESTest is clinically relevant in specialized pain care, given its measurement properties and associations with opioid use and biopsychosocial factors influencing treatment outcomes. However, it does not fully capture balance as experienced in everyday life, leaving unmet needs in assessment and treatment. Based on findings from this thesis, a conceptual model grounded in behavioral medicine is introduced, emphasizing the need for multidimensional approaches reflecting patients’ everyday challenges and abilities to participate in meaningful activities. These findings underscore importance of integrating patient-reported experiences and contextual factors into balance assessment and treatment.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2025. , p. 87
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 2183
Keywords [en]
Behavioral Medicine, Biopsychosocial Models, Chronic pain, Opioid Analgesics, Pain Clinics, Physiotherapy, Postural Balance, Psychometrics
National Category
Physiotherapy
Research subject
Medical Science
Identifiers
URN: urn:nbn:se:uu:diva-567617ISBN: 978-91-513-2599-6 (print)OAI: oai:DiVA.org:uu-567617DiVA, id: diva2:1999602
Public defence
2025-11-07, Sal IX, Universitetshuset, Biskopsgatan 3, Uppsala, 09:15 (Swedish)
Opponent
Supervisors
Available from: 2025-10-17 Created: 2025-09-21 Last updated: 2025-10-17
List of papers
1. Construct validity of the Mini-BESTest in individuals with chronic pain in specialized pain care
Open this publication in new window or tab >>Construct validity of the Mini-BESTest in individuals with chronic pain in specialized pain care
2023 (English)In: BMC Musculoskeletal Disorders, E-ISSN 1471-2474, Vol. 24, no 1, article id 391Article in journal (Refereed) Published
Abstract [en]

Background

Balance assessment scales are important clinical tests to identify balance impairments. Chronic pain (> 3 months) is associated with impaired dynamic balance; however, very few balance assessment scales are psychometrically evaluated for the population. The purpose of this study was to evaluate the construct validity and internal consistency of the Mini-BESTest for individuals with chronic pain in specialized pain care.

Methods

In this cross-sectional study, 180 individuals with chronic pain (> 3 months) were assessed with the Mini-BESTest and included in the analyses. For construct validity, five alternative factor structures were evaluated using a confirmatory factor analysis. In addition, we tested the a priori hypotheses about convergent validity with the 10-meter walk test, and divergent validity with the Brief Pain Inventory (BPI): pain intensity, the Tampa Scale of Kinesiophobia-11 (TSK-11), and the Pain Catastrophizing Scale (PCS-SW). Internal consistency was evaluated for the model with the best fit.

Results

A one-factor model with added covariance via the modification indices showed adequate fit indices. In line with our hypotheses, Mini-BESTest showed convergent validity (rs = > 0.70) with the 10-meter walk test, and divergent validity (rs = < 0.50) with BPI pain intensity, TSK-11, and PCS-SW. Internal consistency for the one-factor model was good (α = 0.92).

Conclusions

Our study supported the construct validity and internal consistency of the Mini-BESTest for measuring balance in individuals with chronic pain, who were referred to specialized pain care. The one-factor model showed an adequate fit. In comparison, models with subscales did not reach convergence, or showed high correlations between subscales, implying that Mini-BESTest is measuring one construct in this sample. We, therefore, propose using the total score, instead of subscale scores, for individuals with chronic pain. However, further studies are necessary to establish the reliability of the Mini-BESTest in the population.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2023
Keywords
Chronic pain, Specialized pain care, Balance, Mini-BESTest, Validity, Internal consistency
National Category
Physiotherapy Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:uu:diva-503102 (URN)10.1186/s12891-023-06504-9 (DOI)000989205400001 ()37198616 (PubMedID)
Funder
Swedish Research Council, 2016−01582Region UppsalaGovernment of SwedenUppsala University
Available from: 2023-06-08 Created: 2023-06-08 Last updated: 2025-09-21Bibliographically approved
2. Balance in clinical testing and everyday life is not the same: Patients’ perceptions and test-retest reliability of the Mini-BESTest in chronic pain
Open this publication in new window or tab >>Balance in clinical testing and everyday life is not the same: Patients’ perceptions and test-retest reliability of the Mini-BESTest in chronic pain
(English)Manuscript (preprint) (Other academic)
National Category
Physiotherapy
Identifiers
urn:nbn:se:uu:diva-567612 (URN)
Available from: 2025-09-19 Created: 2025-09-19 Last updated: 2025-09-21
3. Clinical and opioid-related factors associated with balance in patients with chronic non-malignant pain: A cross-sectional study
Open this publication in new window or tab >>Clinical and opioid-related factors associated with balance in patients with chronic non-malignant pain: A cross-sectional study
Show others...
(English)Manuscript (preprint) (Other academic)
National Category
Physiotherapy
Identifiers
urn:nbn:se:uu:diva-567613 (URN)
Available from: 2025-09-19 Created: 2025-09-19 Last updated: 2025-09-21
4. Opioid Use and Prescription Opioid Use Disorder: Biopsychosocial Characterisation of a Clinical Chronic Pain Cohort
Open this publication in new window or tab >>Opioid Use and Prescription Opioid Use Disorder: Biopsychosocial Characterisation of a Clinical Chronic Pain Cohort
Show others...
2025 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 29, no 7, article id e70081Article in journal (Refereed) Published
Abstract [en]

Background: This study aimed to examine: (a) characteristics associated with long-term opioid use and (b) characteristics associated with problematic opioid use, here defined as prescription opioid use disorder (P-OUD), in patients referred to specialised pain care.

Methods: This cross-sectional study utilised baseline data from a clinical chronic pain cohort. Eligible participants included adults > 18 years old, not undergoing cancer treatment, had pain > 3 months, and had been referred to a specialised pain care centre in Sweden. Bivariate logistic regression and multivariable logistic regression with forward selection were used to examine the associations between biopsychosocial variables and either long-term opioid use or P-OUD.

Results: Of the 339 patients included, 194 (57%) were using opioids, 159 (47%) had long-term opioid use (> 90 days), and 34 (21% of those with long-term opioid use) had P-OUD. Longer pain duration, unemployment, more pain catastrophising, lower health-related quality of life, and worse balance increased the likelihood of long-term opioid use. Long-term use of high doses was associated with a greater prevalence of psychiatric and cognitive-behavioural problems compared to long-term use at low to moderate doses. Long-term opioid use, younger age, trauma exposure, more pain catastrophising, and fear of movement increased the likelihood of P-OUD.

Conclusions: Our results demonstrate the importance of identifying and treating salient factors that may sustain both the pain condition and long-term opioid use. Many of the biopsychosocial variables associated with long-term opioid use and P-OUD can be addressed within interdisciplinary pain management and rehabilitation programmes.

Place, publisher, year, edition, pages
John Wiley & Sons, 2025
National Category
Drug Abuse and Addiction Public Health, Global Health and Social Medicine
Identifiers
urn:nbn:se:uu:diva-566293 (URN)10.1002/ejp.70081 (DOI)001535062200005 ()40682395 (PubMedID)2-s2.0-105011257466 (Scopus ID)
Funder
Swedish Research Council, 2016-01582Vinnova, 2016-01582
Available from: 2025-09-08 Created: 2025-09-08 Last updated: 2025-09-21Bibliographically approved

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