Open this publication in new window or tab >>Show others...
2025 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 29, no 7, article id e70081Article in journal (Refereed) Published
Abstract [en]
Background: This study aimed to examine: (a) characteristics associated with long-term opioid use and (b) characteristics associated with problematic opioid use, here defined as prescription opioid use disorder (P-OUD), in patients referred to specialised pain care.
Methods: This cross-sectional study utilised baseline data from a clinical chronic pain cohort. Eligible participants included adults > 18 years old, not undergoing cancer treatment, had pain > 3 months, and had been referred to a specialised pain care centre in Sweden. Bivariate logistic regression and multivariable logistic regression with forward selection were used to examine the associations between biopsychosocial variables and either long-term opioid use or P-OUD.
Results: Of the 339 patients included, 194 (57%) were using opioids, 159 (47%) had long-term opioid use (> 90 days), and 34 (21% of those with long-term opioid use) had P-OUD. Longer pain duration, unemployment, more pain catastrophising, lower health-related quality of life, and worse balance increased the likelihood of long-term opioid use. Long-term use of high doses was associated with a greater prevalence of psychiatric and cognitive-behavioural problems compared to long-term use at low to moderate doses. Long-term opioid use, younger age, trauma exposure, more pain catastrophising, and fear of movement increased the likelihood of P-OUD.
Conclusions: Our results demonstrate the importance of identifying and treating salient factors that may sustain both the pain condition and long-term opioid use. Many of the biopsychosocial variables associated with long-term opioid use and P-OUD can be addressed within interdisciplinary pain management and rehabilitation programmes.
Place, publisher, year, edition, pages
John Wiley & Sons, 2025
National Category
Drug Abuse and Addiction Public Health, Global Health and Social Medicine
Identifiers
urn:nbn:se:uu:diva-566293 (URN)10.1002/ejp.70081 (DOI)001535062200005 ()40682395 (PubMedID)2-s2.0-105011257466 (Scopus ID)
Funder
Swedish Research Council, 2016-01582Vinnova, 2016-01582
2025-09-082025-09-082025-09-21Bibliographically approved