Logo: to the web site of Uppsala University

uu.sePublications from Uppsala University
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Nutritional therapy post-burn injury: Adherence to guidelines and an analysis of nutritional interventions and barriers
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Plastic Surgery. (Plastikkirurgi)ORCID iD: 0000-0003-2806-5159
2026 (English)Doctoral thesis, comprehensive summary (Other academic)
Description
Abstract [en]

Objective: Insufficient nutritional intake can impair wound healing and increase the risk of complications post burn. The overall aim of this thesis was to examine nutritional therapy post burn in relation to the extent of the burn. This was accomplished by examining adherence to nutritional guidelines (Study I), documented interventions and barriers (Study II), and symptoms affecting appetite and eating post injury (Study III-IV).

Methods: Study I evaluated documented nutritional therapy in relation to guidelines during first 12 days post burn by conducting medical record review. Study II explored differences in documentation of nutritional interventions and barriers between patients post-minor and major burn by performing medical record review and content analysis. Study III modified questionnaires Disease Related Appetite Questionnaire (DRAQ) and Eating Symptom Questionnaire (ESQ) to measure nutrition impact symptoms (NIS) 6-12 months post burn by undertaken expert panel review, cognitive interviews and expert consultation on terminology. Study IV investigated the differences in prevalence of NIS using questionnaires DRAQ-burn and ESQ-burn.

Results: Study I found low adherence to nutritional guidelines and low adequacy of intake compared to individual goals, particularly after minor burns. Study II showed that interventions targeting meal and meal support were rarely documented compared to medical nutritional therapy, despite most patients having oral intake. Barriers to nutritional therapy were common with fasting and gastrointestinal symptoms being the most frequently documented. Significantly more interventions and barriers were documented for patients post-major burn compared to post-minor burn. In Study III high expert consensus on the adapted questionnaires DRAQ-burn and ESQ-burn was achieved. Study IV revealed prevalences of median 1-2 NIS at 6 months that persisted up to 12 months post injury. There was no difference in the prevalence of NIS post-minor compared to post-major burn.

Conclusions: The overall low adherence to nutritional guidelines, inadequate achievement of individual intake goals, the frequent documentation of barriers to nutritional interventions, and the persistent prevalence of nutrition impact symptoms indicate a risk of insufficient nutritional therapy following burn. The findings highlight the need for continuous nutritional assessment, evaluation and monitoring of nutritional therapy throughout the burn care trajectory regardless of burn extent. 

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2026. , p. 82
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 2226
Keywords [en]
Burn, Nutrition, Nutritional therapy, Intervention, Barrier, Nutrition impact symptom, guideline
National Category
Clinical Medicine
Research subject
Medical Science
Identifiers
URN: urn:nbn:se:uu:diva-576103ISBN: 978-91-513-2717-4 (print)OAI: oai:DiVA.org:uu-576103DiVA, id: diva2:2028292
Public defence
2026-03-06, H:son Holmdahlsalen, Uppsala University hospital, entrance 100, 2nd floor, Dag Hammarskjölds väg 8, Uppsala, 09:15 (English)
Opponent
Supervisors
Available from: 2026-02-13 Created: 2026-01-14 Last updated: 2026-02-13
List of papers
1. Documented nutritional therapy in relation to nutritional guidelines post burn injury: a retrospective observational study
Open this publication in new window or tab >>Documented nutritional therapy in relation to nutritional guidelines post burn injury: a retrospective observational study
Show others...
2023 (English)In: Clinical Nutrition ESPEN, E-ISSN 2405-4577, Vol. 56, p. 222-229Article in journal (Refereed) Published
Abstract [en]

Background & aims: Intensive nutritional therapy is an essential component of burn care. Regardingpost-minor burn injuries, the literature is lacking. The aim of this study was to evaluate documentednutritional therapy in relation to international guidelines after both minor and major burn injuries. The secondary aim of this study was to evaluate the adequacy of energy and protein intake compared toindividual nutritional goals post-burn injury.

Methods: A retrospective observational single-centre study including patients admitted between 2017and 2019 at a burn centre in Sweden was performed. The patients included in the study were >18 years old and in need of hospital care for > 72 h post-burn injury. Information about patients' demographics,nutritional therapy, and clinical characteristics of burn injury was collected. The patients were dividedaccording to total body surface area burnt (TBSA %) into minor burn injuries (TBSA <20%) and major burninjuries (TBSA >20%). Descriptive statistics were used to analyse data. Adherence to guidelines wasestablished by comparing 24 nutritional therapy recommendations to documented treatment. If documented nutritional treatment were in accordance with guidelines, adherence was considered high(>80%), moderate (60-79.9%) or low (<59.9%).

Results: One hundred thirty-four patients were included, 90 patients with minor burn injuries and 44patients with major burn injuries. Documented adherence to the nutritional guideline was overall low.After minor burn injury, 8% (2/24) of nutritional therapy recommendations had a high adherence (fatintake <35% of total energy intake and enteral nutrition as prioritized feeding route), 17% (4/24) amoderate adherence, and 75% (18/24) a low adherence. In patients treated after a major burn injury,there were two recommendations with documented high adherence (Vitamin C and Zinc); 25% (6/24)had moderate adherence, and 67% (16/24) had low adherence. In addition, quite a large amount ofmissing data was found.Adequacy of documented nutritional intake, compared to the individual documented goal, was 78%(±23%) for energy and 66% (±22%) for protein after minor burn injury. After major burn injury, the adequacy was 89% (±21%) for energy and 78% (±19%) for protein, respectively.

Conclusions: This study revealed low adherence to nutritional guidelines in patients treated for minorand major burn injuries. Compared to major burn injuries, lower documented adequacy for both energyand proteins was found in minor burn injuries. Given the disparity between guidelines and documentednutritional therapy, and the lack of specific guidelines for minor burn injuries, there could be aconsiderable risk of inadequate nutritional therapy post-burn injury.

Place, publisher, year, edition, pages
Elsevier, 2023
National Category
Anesthesiology and Intensive Care
Research subject
Nutrition
Identifiers
urn:nbn:se:uu:diva-508395 (URN)10.1016/j.clnesp.2023.06.003 (DOI)001027857900001 ()37344077 (PubMedID)
Available from: 2023-07-31 Created: 2023-07-31 Last updated: 2026-01-14Bibliographically approved
2. Nutritional interventions and barriers for patients early after burn injury: A retrospective evaluation of medical records
Open this publication in new window or tab >>Nutritional interventions and barriers for patients early after burn injury: A retrospective evaluation of medical records
2025 (English)In: Clinical Nutrition Open Science, E-ISSN 2667-2685, Vol. 62, p. 218-232Article in journal (Refereed) Published
Abstract [en]

Background & aims Inadequate intake and barriers to nutritional therapy are challenges in burn care. Post-burn injury nutritional care practices are rarely reported, particularly after minor injuries. The aim of this study was to describe nutritional interventions, identify barriers to nutritional intervention, and compare the documentation of nutrition for patients after minor and major burn injuries.

Methods A retrospective single-centre medical record review was conducted on patients aged 18 and older who were admitted for more than 72 h between 2017 and 2019 at one of Sweden's two national burn centres. A content analysis and descriptive statistics were used to analyse the data, and differences were explored between patients with minor and major burn injuries.

Results A total of 134 patients were included in the study: 90 patients had minor burn injuries (mean total burn surface area (TBSA) 8.1 % ± 5.0), and 44 patients had major burn injuries (mean TBSA 37.8 % ± 17.2). Nutritional supplement therapy (93 %) and nutrition prescription (91 %) were the most common interventions. Interventions targeting meals and snacks (43 %) and meal support (40 %), were documented less frequently. Fasting (93 %) and gastrointestinal symptoms (49 %) were the most common barriers.Significantly more interventions (including enteral/parenteral nutrition, and vitamin/mineral supplementation) and barriers (primarily related to enteral nutrition and fasting) were documented for patients with major burn injuries.

Conclusion This study concludes that while most patients have oral intake, vitamin and mineral supplementation and medical nutritional therapy were more frequently documented than meal/snack interventions and meal support. The lack of dietary interventions, whether unperformed or undocumented, needs further investigation. Frequent documentation of barriers to nutritional interventions suggests that patients post-burn injury are at risk of inadequate energy and protein intake. Therefore, emphasising nutritional therapy and its documentation in post-burn care is crucial, regardless of burn severity.

Place, publisher, year, edition, pages
Elsevier, 2025
National Category
Surgery Nutrition and Dietetics Nursing
Research subject
Medical Science
Identifiers
urn:nbn:se:uu:diva-564219 (URN)10.1016/j.nutos.2025.06.007 (DOI)2-s2.0-105009607214 (Scopus ID)
Available from: 2025-07-30 Created: 2025-07-30 Last updated: 2026-01-14Bibliographically approved
3. Two Modified Questionnaires for the Assessment of Nutrition Impact Symptoms in the Rehabilitation Phase after Burn Injury: A Content Validation Study
Open this publication in new window or tab >>Two Modified Questionnaires for the Assessment of Nutrition Impact Symptoms in the Rehabilitation Phase after Burn Injury: A Content Validation Study
2022 (English)In: European Burn Journal, E-ISSN 2673-1991, Vol. 3, no 1, p. 156-164Article in journal (Refereed) Published
Abstract [en]

Disease Related Appetite Questionnaire (DRAQ) and Eating Symptom Questionnaire(ESQ) are used to assess nutrition impact symptoms, which are symptoms that can negatively affectthe patients’ food intake. However, these questionnaires have not yet been adapted to the needsof patients recovering from burn injuries. Our aim was therefore to develop DRAQ and ESQ forassessments of nutrition impact symptoms after burn injury. A content validation index (I-CVI) foritems included in DRAQ and ESQ, regarding their relevance for possible nutrition impact symptomsin a burn-injured patient (Likert scale 1–4), was performed by an expert review group. A clarityvalidation by expert and non-expert reviewers was carried out. Two of the eleven questions inDRAQ and eight of the fourteen questions in ESQ were not considered relevant and were thereforeremoved from the questionnaires. Five additional questions were added to DRAQ and two to ESQ.A high degree of consensus on relevance (scale-content validity index average, S-CVI/Ave, 0.86 forDRAQ-burn and 0.83 for ESQ-burn) was reached in the expert group. To conclude, it is suggestedthat we use developed forms of DRAQ and ESQ (DRAQ-burn and ESQ-burn) for the assessment ofnutrition impact symptoms, specifically during the rehabilitation phase of burn-injured patients.

Place, publisher, year, edition, pages
MDPI, 2022
Keywords
burn injury, surveys and questionnaires, questionnaire validation, nutrition impact symptoms
National Category
Nutrition and Dietetics
Research subject
Nutrition
Identifiers
urn:nbn:se:uu:diva-487255 (URN)10.3390/ebj3010013 (DOI)001126843100001 ()
Funder
Region Uppsala
Available from: 2022-10-26 Created: 2022-10-26 Last updated: 2026-01-14Bibliographically approved
4. Nutrition impact symptoms 6-12 months post-burn injury: a single-cohort longitudinal study
Open this publication in new window or tab >>Nutrition impact symptoms 6-12 months post-burn injury: a single-cohort longitudinal study
(English)Manuscript (preprint) (Other academic)
Abstract [en]

Objectives 

This study aimed to investigate long-term prevalence of nutrition impact symptoms, such as appetite and eating-related issues that may impede food intake, in patients with minor- and major-burn injuries.

Methods

In this prospective longitudinal cohort study, sixty adults participated. Two questionnaires, the Disease-Related Appetite Questionnaire (DRAQ-burn) and the Eating Symptom Questionnaire (ESQ-burn), were completed during follow-up visits at six and 12 months post trauma.

Results

Median burn extent was 4.5% in the post-minor burn group and 24.0% in the post-major burn group. At six months, the median number of symptoms reported in DRAQ-burn was 2.0 for all patients; at 12 months, it was 1.0 post-minor burns and 1.5 post-major burns. Reported symptoms in the ESQ-burn remained stable at a median of 1.0 across both time points and burn severities. Most frequently reported symptoms included fluctuation in appetite/eating, never/rarely feeling hungry, tiredness affecting appetite/eating and nausea. No statistically significant differences were found between burn severity groups or over time.

Conclusion

Overall, although the nutrition impact symptoms were reported to be more mild than severe in nature, they persisted for up to a year post burn, highlighting the need for ongoing nutritional follow-up to mitigate the risk of malnutrition.

Keywords
Burn injury, Nutrition impact symptoms
National Category
Anesthesiology and Intensive Care Rehabilitation Medicine Nutrition and Dietetics
Research subject
Medical Science
Identifiers
urn:nbn:se:uu:diva-576047 (URN)
Available from: 2026-01-14 Created: 2026-01-14 Last updated: 2026-01-21

Open Access in DiVA

UUThesis_Dimander,J-2026(791 kB)37 downloads
File information
File name FULLTEXT01.pdfFile size 791 kBChecksum SHA-512
01bc21fd77b674025a4f95a0d2eb5dfd9996ea0811a690b236fe4aaf1920e271b1f1c6294c5a310fe673323276d92f4a5809910b170d88cceb40f5de21441fcd
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Dimander, Josefin
By organisation
Plastic Surgery
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
Total: 1160 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf