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Tibial Plateau Fractures: Long-term Outcomes and Conversion to Total Knee Arthroplasty
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics and Handsurgery.
2026 (English)Doctoral thesis, comprehensive summary (Other academic)
Description
Abstract [en]

Tibial plateau fractures (TPFs) encompass a broad spectrum of injuries, ranging from simple, undisplaced splits to complex intra-articular fracture patterns. These fractures are frequently associated with long-term sequelae, most notably post-traumatic osteoarthritis (PTOA) and eventual conversion to total knee arthroplasty (TKA). As the incidence of fragility fractures is projected to rise within expanding ageing populations, the burden of TPF-related knee degeneration is expected to increase substantially. Despite advances in internal fixation techniques, uncertainty persists regarding long-term clinical outcomes, the risk factors driving joint deterioration, and the potential role of primary arthroplasty for selected patients.

The overarching aim of this thesis was to investigate the long-term consequences of TPF, with focus on epidemiology, the progression to TKA, and the role of patient- and fracture-related characteristics in risk stratification for joint conversion. This objective was addressed through a series of longitudinal cohort studies, leveraging both single-centre clinical data and comprehensive national register-based datasets. First, national incidence patterns and mortality rates following TPF were evaluated using the National Patient Register (NPR). A single-centre cohort study linked to the Swedish Arthroplasty Register (SAR) was used to identify factors associated with subsequent TKA conversion. Subsequently, national data from the SFR were linked to the SAR to examine the association between fracture severity and TKA conversion within a large, population-based cohort. Finally, SAR data were analysed to evaluate clinical outcomes following acute TKA as a primary treatment for TPF, with these results compared against outcomes of delayed TKA performed for PTOA.

Findings from this thesis indicate that although most TPFs managed with ORIF have low TKA conversion rates, a distinct subset of patients faces an elevated risk of conversion. This high-risk group is characterised by severe fracture patterns, advanced age, and inadequate postoperative reduction. Moreover, TKA following TPF often resembles revision surgery rather than primary arthroplasty in terms of surgical complexity, implant selection, and clinical outcomes. Consequently, acute arthroplasty in carefully selected high-risk individuals may serve as a viable primary intervention with favourable results.

In conclusion, this thesis offers new insights into the trajectory from fracture to arthroplasty following TPF. The findings underscore the critical importance of achieving high-quality anatomical reduction, early stratification of patients at elevated risk of failure, and individualised decision-making regarding joint preservation versus primary arthroplasty. Collectively, these findings advance clinical understanding and provide a foundation for future research aimed at refining treatment strategies and improving long-term outcomes.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2026. , p. 108
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 2228
Keywords [en]
Tibial Plateau Fractures, Knee Arthroplasty, Trauma, Lower Leg, Epidemiology
National Category
Orthopaedics
Identifiers
URN: urn:nbn:se:uu:diva-577031ISBN: 978-91-513-2725-9 (print)OAI: oai:DiVA.org:uu-577031DiVA, id: diva2:2030282
Public defence
2026-03-13, Gunnesalen, Akademiska sjukhuset, Ingång 10, Uppsala, 12:00 (English)
Opponent
Supervisors
Available from: 2026-02-17 Created: 2026-01-20 Last updated: 2026-02-17
List of papers
1. Incidence of Proximal Tibia Fractures: Women Have Twice the Rate and Young Women Show a Twofold Increase - a national 13-year observational study
Open this publication in new window or tab >>Incidence of Proximal Tibia Fractures: Women Have Twice the Rate and Young Women Show a Twofold Increase - a national 13-year observational study
(English)Manuscript (preprint) (Other academic)
National Category
Orthopaedics
Research subject
Medical Science
Identifiers
urn:nbn:se:uu:diva-577030 (URN)
Available from: 2026-01-20 Created: 2026-01-20 Last updated: 2026-01-20
2. Risk of conversion to total knee arthroplasty after surgically treated tibial plateau fractures: an observational cohort study of 439 patients
Open this publication in new window or tab >>Risk of conversion to total knee arthroplasty after surgically treated tibial plateau fractures: an observational cohort study of 439 patients
2024 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 95, p. 206-211Article in journal (Refereed) Published
Abstract [en]

Background and purpose: We aimed to assess joint failure rate, i.e., subsequent conversion to TKA after surgical treatment of a tibial plateau fracture (TPF). Secondary aims were to explore the association between joint failure and fracture type, and to determine the risk of failure associated with inadequate joint surface reduction.

Methods: We included all patients ≥ 18 years of age with a surgically treated TPF, treated at Uppsala University Hospital between 2002 and 2015. All fractures were classified according to the Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Traumatology Association (AO/OTA) classification. Postoperative radiographs were evaluated to determine the quality of joint surface inadequate reduction, defined as an articular step-off ≥ 2 mm. The study cohort was linked with the Swedish Arthroplasty Register (SAR) for information on subsequent total knee arthroplasty (TKA).

Results: 439 patients (57% women) with a mean age of 55 years (SD 17) were included. According to the AO/OTA classification, the fracture distribution was B1: 4.8%, B2: 10%, B3: 47%, C1: 12%, C2: 6.4%, and C3: 19%. 23 patients (5.2%) were converted to a TKA within 2 years of initial surgery, and 34 patients (7.7%) had been converted by the end of follow-up (16 years). AO/OTA type B3 and C3 had a 6.8 (95% confidence interval [CI] 1.6–29) times greater risk of joint failure compared with B1–2 and C1–C2 at 2 years’ follow-up. Inadequate joint surface reduction led to an 8.4 (CI 3.6–20) times greater risk of conversion to TKA at 2 years’ follow-up.

Conclusion: Overall, 5.2% were converted to a TKA within 2 years. Fracture types AO/OTA B3 and C3 with a comminuted articular surface and inadequate joint surface reduction were strongly associated with joint failure.

Place, publisher, year, edition, pages
Medical Journals Sweden, 2024
National Category
Orthopaedics Surgery
Identifiers
urn:nbn:se:uu:diva-530450 (URN)10.2340/17453674.2024.40605 (DOI)001227327600001 ()38712764 (PubMedID)
Available from: 2024-06-05 Created: 2024-06-05 Last updated: 2026-01-20Bibliographically approved
3. Fractures with complex fracture patterns are associated with increased rate of subsequent conversion to total knee arthroplasty after a tibial plateau fracture: an observational cohort study of 12,012 patients from the Swedish Fracture Register
Open this publication in new window or tab >>Fractures with complex fracture patterns are associated with increased rate of subsequent conversion to total knee arthroplasty after a tibial plateau fracture: an observational cohort study of 12,012 patients from the Swedish Fracture Register
2025 (English)In: KNEE SURGERY & RELATED RESEARCH, ISSN 2234-2451, Vol. 37, article id 27Article in journal (Refereed) Published
Abstract [en]

Background: Tibial plateau fractures (TPFs) can be associated with development of significant joint degeneration, which can lead to functional impairment and pain severe enough to necessitate conversion to total knee arthroplasty (TKA). The factors influencing the progression to TKA after TPF, including preoperative fracture and patient characteristics, remain unclear. This study aimed to assess the national conversion rate to TKA following TPF depending on fracture type.

Patients and methods: The cohort consisted of all patients aged 18 years and older at time of injury with a TPF registered in the Swedish Fracture Register (SFR) between 2012 and 2023. The SFR holds information on baseline patient characteristics including fracture classification according to the AO/OTA system. Conversion to TKA was identified through linkage with the Swedish Arthroplasty Register (SAR). Kaplan-Meier survival analyses investigated conversion rate. Cox regression was performed to assess association between fracture type and TKA conversion adjusted for age, sex, and injury energy level. The follow-up period ranged from 0 to 12 years, with a mean of 4.2 years.

Results: A total of 12,012 patients with a mean age of 57 years were included; 63% were women. The observed conversion rate after 5 years was 2.8% in all patients and 4.1% in surgically treated patients. The conversion rate at 5 years was highest in the 65-74 years age group with 5.2%. Fractures with comminuted fracture patterns, particularly AO/OTA 41B3, 41C2, and 41C3, were associated with significantly increased risks of conversion, with adjusted hazard ratios (aHRs) of 2.1 (95% CI 1.3-3.3), 2.3 (1.2-4.5), and 3.2 (95% CI 2.0-4.5), respectively. High-energy trauma did not increase the risk of conversion, nor did sex. Increasing age was associated with an increased risk of conversion up to the age of 84, while age over 85 was not.

Conclusions: Fractures with complex fracture patterns, particularly AO/OTA 41B3, 41C2, and 41C3, were associated with an increased TKA conversion rate following TPF. The conversion rate increased with increasing age, but sex and high-energy injury mechanisms did not affect conversion rate. On a national level, 3% of patients were converted to TKA within 5 years of sustaining a TPF, and 4% of patients treated surgically. This may help surgeons when counseling patients with TPFs.

Place, publisher, year, edition, pages
Springer Nature, 2025
Keywords
Knee, Tibial plateau fractures, Total knee arthroplasty, Trauma, Lower extremity, Arthroplasty
National Category
Orthopaedics Surgery
Identifiers
urn:nbn:se:uu:diva-561344 (URN)10.1186/s43019-025-00279-0 (DOI)001503366600001 ()40481589 (PubMedID)
Available from: 2025-06-26 Created: 2025-06-26 Last updated: 2026-01-20Bibliographically approved
4. Acute or Delayed TKA for Tibial Plateau Fracture? An Observational Study From the Swedish Arthroplasty Register
Open this publication in new window or tab >>Acute or Delayed TKA for Tibial Plateau Fracture? An Observational Study From the Swedish Arthroplasty Register
Show others...
(English)Manuscript (preprint) (Other academic)
National Category
Orthopaedics
Research subject
Medical Science
Identifiers
urn:nbn:se:uu:diva-577029 (URN)
Available from: 2026-01-20 Created: 2026-01-20 Last updated: 2026-01-20

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