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The Electronic Psychiatric Semi-structured Interview for Children and Adolescents (EPSI-C): development and psychometric evaluation of an open-access DSM-5-based diagnostic instrument
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Centre for Clinical Research, County of Västmanland. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Child and Adolescent Psychiatry.ORCID iD: 0000-0002-8114-8386
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Centre for Clinical Research, County of Västmanland. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Child and Adolescent Psychiatry.ORCID iD: 0009-0005-2155-0188
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Child and Adolescent Psychiatry. Karolinska Inst, Ctr Neurodev Disorders KIND, Ctr Psychiat Res, Dept Womens & Childrens Hlth, Stockholm, Sweden; Stockholm Hlth Care Serv, Reg Stockholm, Stockholm, Sweden.ORCID iD: 0000-0003-1033-2618
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Centre for Clinical Research, County of Västmanland. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Child and Adolescent Psychiatry. Mälardalen Univ, Sch Hlth Care & Social Welf, Div Publ Hlth Sci, Västerås, Sweden.ORCID iD: 0000-0002-8853-2508
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2026 (English)In: Child and Adolescent Psychiatry and Mental Health, E-ISSN 1753-2000, Vol. 20, no 1, article id 67Article in journal (Refereed) Published
Abstract [en]

Background

Standardized diagnostic interviews are essential tools for accurate assessment in child and adolescent psychiatry (CAP). However, many existing interviews are restricted by licensing costs, platform dependencies, limited clinical adaptability, or legal ambiguity regarding digital implementation. To address these limitations, the Electronic Psychiatric Semi-structured Interview for Children and Adolescents (EPSI-C) was developed as an open-access, platform-independent instrument aligned with the DSM-5. The modular structure, comprising 22 modules covering the full range of common psychiatric disorders, allows for both systematic and targeted administration. This instrument development and psychometric validation study evaluated the content validity and internal consistency of the EPSI-C.

Methods

Content validity was assessed by ten independent experts who rated the relevance of the instrument for assessing DSM-5 diagnostic criteria. Additionally, experts rated six global aspects of clinical utility. Internal consistency was examined in a large naturalistic sample of 3,506 patients (mean age = 12.0 years, SD = 3.2, range 5–18 years; 54.5% girls) assessed with a digital implementation of the EPSI-C during routine outpatient CAP assessments in Sweden.

Results

The EPSI-C demonstrated excellent scale-level average content validity for both the screening sections (S-CVI/Ave = 0.95) and full modules (S-CVI/Ave = 0.94). Expert consensus was high (90–100%) regarding overall clinical utility. Internal consistency was acceptable to excellent (α range 0.71 – 0.90) for 87.5% of eligible modules. Lower consistency was observed for modules assessing psychotic disorders (α = 0.53) and anorexia nervosa (α = 0.49), reflecting limited DSM-5 criteria and sub-threshold presentations.

Conclusions

The findings support the foundational psychometric properties of the EPSI-C and indicate its clinical feasibility within a high-volume, naturalistic CAP outpatient setting. The current study establishes content validity and internal consistency, while criterion validity remains to be evaluated. As an open-access, modular instrument, EPSI-C offers a scalable solution for the digital implementation of standardized diagnostic interviews in routine clinical practice.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2026. Vol. 20, no 1, article id 67
Keywords [en]
EPSI-C, Diagnostic interview, Child and adolescent psychiatry, DSM-5, Content validity, Internal consistency, Digital implementation, eHealth
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-586504DOI: 10.1186/s13034-026-01094-5ISI: 001759077700001PubMedID: 42093030OAI: oai:DiVA.org:uu-586504DiVA, id: diva2:2061061
Note

De två första författarna delar förstaförfattarskapet

Available from: 2026-05-20 Created: 2026-05-20 Last updated: 2026-05-20Bibliographically approved

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Olofsdotter, SusanneDragou, MelpomeniIsaksson, JohanNilsson, Kent W.Vadlin, SofiaHedqvist, Maria

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Olofsdotter, SusanneDragou, MelpomeniIsaksson, JohanNilsson, Kent W.Vadlin, SofiaHedqvist, Maria
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Centre for Clinical Research, County of VästmanlandChild and Adolescent PsychiatryDepartment of Psychology
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Child and Adolescent Psychiatry and Mental Health
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