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Non-motor symptoms and their use as markers for prodromal and early Parkinson's disease
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2021 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is a disease with a broad spectrum of symptoms, both motor and non-motor, but is often only diagnosed when the motor symptoms begin to appear. By this time however, a large amount of the dopaminergic neurons of the substantia nigra pars compacta have already deteriorated. It is therefore of great interest to be able to diagnose the disease earlier on in its progression and perhaps slow down or halt its course. Recent literature has supported the idea that non-motor symptoms begin to appear years, perhaps even decades, before the motor symptoms are visible. This makes them a prime candidate for diagnosing PD earlier on. With the aim of assessing the prevalence of different NMS in prodromal and early Parkinson’s, 19 studies addressing different NMS were analyzed. It was found that NMS are prevalent in both prodromal and early PD. The strongest prodromal predictors for PD were found to be olfactory dysfunction and REM-sleep behavior disorder (RBD). 

Place, publisher, year, edition, pages
2021. , p. 37
Keywords [en]
Neurology, Parkinson's, non-motor symptom, prodromal
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-445208OAI: oai:DiVA.org:uu-445208DiVA, id: diva2:1564337
Educational program
Bachelor Programme in Biology / Molecular Biology
Presentation
2021-06-07, Zoom, 11:30 (English)
Supervisors
Examiners
Available from: 2021-06-17 Created: 2021-06-11 Last updated: 2021-06-17Bibliographically approved

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NMS of PD(1911 kB)84 downloads
File information
File name FULLTEXT01.pdfFile size 1911 kBChecksum SHA-512
12826d409087fdffea3fc92c4ea8cb255afaa564e8030e27bbdec9ec0617a0e85fc0c8f467b3bd89ca7638f2cd6ba7fc92b5f49108e705462065d5efd9fd202e
Type fulltextMimetype application/pdf

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Department of Organismal BiologyBiology Education Centre
Neurology

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf