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Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of Dalbergia gloveri
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC. Univ Nairobi, Dept Chem, Nairobi 3019700100, Kenya.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Organic Chemistry.ORCID iD: 0000-0003-4617-7605
Univ Nairobi, Dept Chem, Nairobi 3019700100, Kenya..ORCID iD: 0000-0001-8337-9260
Univ Nairobi, Dept Biol, Nairobi 3019700100, Kenya..
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2024 (English)In: Journal of Natural Products, ISSN 0163-3864, E-ISSN 1520-6025, Vol. 87, no 9, p. 2263-2271Article in journal (Refereed) Published
Abstract [en]

Three new dihydroflavonols, gloverinols A–C (13), a new flavon-3-ol, gloverinol D (4), two new isoflavans, gloveriflavan A (5) and B (6), and seven known compounds were isolated from the root bark of Dalbergia gloveri. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B (2), gloveriflavan B (6), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone (10) were the most active against Staphylococcus aureus, with MIC values of 9.2, 18.4, and 14.2 μM, respectively.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2024. Vol. 87, no 9, p. 2263-2271
National Category
Organic Chemistry
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URN: urn:nbn:se:uu:diva-541418DOI: 10.1021/acs.jnatprod.4c00690ISI: 001310371100001PubMedID: 39255387OAI: oai:DiVA.org:uu-541418DiVA, id: diva2:1909444
Part of project
Exploration of East African Medicinal Herbs in the Search for Novel Antibacterial Agents, Swedish Research Council
Funder
Swedish Research Council, 2019-03715Uppsala UniversityAvailable from: 2024-10-30 Created: 2024-10-30 Last updated: 2024-10-30Bibliographically approved

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Wieske, Lianne H. E.Xiong, RuishengErdelyi, Mate

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Wieske, Lianne H. E.Nchiozem-Ngnitedem, Vaderament-AlexeUmereweneza, DanielXiong, RuishengKarpinski, Tomasz M.Yenesew, AbiyErdelyi, Mate
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Department of Chemistry - BMCOrganic Chemistry
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