Handovers in Human-Computer Interaction (HCI) have so far been treated as a matter of giving control of technology from one to another actor, for example in the handovers of car control in semi-autonomous driving, digital object handoffs in VR, use of smart technology for information sharing, or simply the handovers of app control from mobile phones to laptops. However, handovers are a huge area of HCI research, since it is an essential component of everyday work practices in numerous work domains, with examples such as handovers of information between work shifts, across departments, or even across organizations. In this conceptual paper, we present prior research on handovers in general, analyze specifically handovers’ socio-technical characteristics, and discuss handovers in various work domains and their cross-domain characteristics. Based on the purpose of handovers, we propose a novel HCI research agenda of Generative AI supported handovers across various work domains.