DiVA - Search result

uu.sePublications from Uppsala University

Planned maintenance

A system upgrade is planned for 10/12-2024, at 12:00-13:00. During this time DiVA will be unavailable.

Simple search

Advanced search -
Research publications Advanced search -
Student theses Statistics

Change search

Advanced search

Advanced search is divided into two main parts, and one or more groups in each of the main parts. The main parts are the "Search for" (including) and the "Remove from search" (excluding) part. (The excluding part might not be visible until you hit "NOT" for the first time.)
You can add new groups to both the including and the excluding part by using the buttons "OR" or "NOT" respectively, and you can add more search options to all groups through the drop down menu on the last row (in each group).

For a result to be included in the search result, is it required to fit all added including parameters (in at least one group) and not fit all parameters in one of the excluding groups.
This system with the two main parts and their groups makes it possible to combine two (or more) distinct searches into one search result, while being flexible in removing results from the final list.

Organisation(id) AX
Browse
Include former name in search

Limit the search further

Here you can limit your search further, your result list will only contain those who match all of the criteria that you fill out in this part (combined with the advanced search from above)

Limit the search further

Select department

Show departments that are closed down

Uppsala University
- Disciplinary Domain of Humanities and Social Sciences
  - Center for Integrated Research on Culture and Society (CIRCUS)
  - Faculty of Arts
    - Centre for Gender Research
    - Department of ALM
      - Centre for Digital Humanities
    - Department of Archaeology and Ancient History
      - African and Comparative Archaeology
      - Archaeology
      - Classical archaeology and ancient history
      - Egyptology
    - Department of Art History
      - Conservation
      - Textile Studies
    - Department of Cultural Anthropology and Ethnology
    - Department of Game Design
    - Department of History of Science and Ideas
    - Department of History
      - The Hugo Valentin Centre
    - Department of Literature and Rhetoric
      - Rhetoric
      - Sociology of Literature
    - Department of Musicology
    - Department of Philosophy
      - Aesthetics
      - Ethics and Social Philosophy
      - Logic and Metaphysics
  - Faculty of Educational Sciences
    - Department of Education
      - Centre for Professional Development and Internationalisation in Schools
  - Faculty of Languages
    - Department of English
      - Celtic Section
      - The Swedish Institute for North American Studies
    - Department of Linguistics and Philology
    - Department of Modern Languages
      - Albanian
      - Finno-Ugric Languages
      - German
      - Romance Languages
      - Slavic Languages
    - Department of Scandinavian Languages
  - Faculty of Law
    - Center for Police Research
    - Department of Law
    - Real Estate Research Institute
  - Faculty of Social Sciences
    - Department of Business Studies
    - Department of Economic History
      - Science and Technology Studies Center
      - Uppsala Centre for Business History
    - Department of Economics
      - Uppsala Center for Fiscal Studies
      - Uppsala Center for Labor Studies (UCLS)
    - Department of Food Studies, Nutrition and Dietetics
    - Department of Government
    - Department of Human Geography
    - Department of Informatics and Media
      - Human-Computer Interaction
      - Information Systems
      - Media and Communication Studies
      - The Swedish IT-User Centre
    - Department of Peace and Conflict Research
    - Department of Psychology
    - Department of Social Work
    - Department of Sociology
    - Department of Statistics
    - Institute for Housing and Urban Research
    - Institute for Russian and Eurasian Studies
  - Faculty of Theology
    - Centre for Multidisciplinary Research on Religion and Society (CRS Uppsala)
    - Centre for Multidisciplinary Studies on Racism
    - Department of Theology
      - Church History and Mission History
      - Empirical-Practical Studies of Religion and Theology
      - Ethics and Philosophy of Religion
      - History of Religions and World Christianity
      - Old and New Testament Exegesis
      - Social Sciences of Religion and Practical Theology
      - Systematic Theology
- Disciplinary Domain of Medicine and Pharmacy
  - Disciplinary Domain of Medicine and Pharmacy, research centers etc.
    - Center for Clinical Research Dalarna
    - Centre for Clinical Research Sörmland
    - Centre for Clinical Research, County of Västmanland
    - Centre for Disability Research
    - Centre for Reproductive Biology in Uppsala (CRU)
    - Centre for Research and Development, Gävleborg
    - CEOS
    - National Centre for Disaster Psychiatry
    - Uppsala Antibiotic Center
    - Uppsala Clinical Research Center (UCR)
  - Faculty of Medicine
    - Department of Immunology, Genetics and Pathology
      - Cancer Immunotherapy
      - Cancer precision medicine
      - Genomics and Neurobiology
      - Molecular Tools and Functional Genomics
      - Neurooncology and neurodegeneration
      - Vascular Biology
    - Department of Medical Biochemistry and Microbiology
      - Biochemistry and Cancer
      - Genetics and Genomics
      - Infection and Immunity
    - Department of Medical Cell Biology
      - Integrative Physiology
      - Research group Dan Larhammar
      - Research Group Karin Nordström
      - Research group Markus Sjöblom/Olof Nylander
      - Research group Mia Lindskog
      - Research group Svante Winberg
    - Department of Medical Sciences
      - Acquired brain injury
      - Autoimmunity
      - Biochemical endocrinology
      - Cancer Pharmacology and Computational Medicine
      - Cardiology-Arrhythmia
      - Cardiology
      - Centre for Health Economics Research (HEFUU)
      - Child and Adolescent Psychiatry
      - Clinical Chemistry
      - Clinical diabetology and metabolism
      - Clinical Epidemiology
      - Clinical Microbiology
      - Clinical Neurophysiology
      - Clinical pharmacogenomics and osteoporosis
      - Clinical Physiology
      - Coagulation and inflammation science
      - Dermatology and Venereology
      - Endocrine Oncology
      - Endocrine Tumor Biology
      - Endocrinology and mineral metabolism
      - Gastroenterology/Hepatology
      - Haematology
      - Health Economics
      - Infection medicine
      - Lung- allergy- and sleep research
      - Molecular epidemiology
      - Molecular Precision Medicine
      - Neurology
      - Neurosurgery
      - Occupational and Environmental Medicine
      - Psychiatry
      - Rehabilitation Medicine
      - Renal Medicine
      - Rheumatology
      - Translationell Neurology
      - Transplantation and regenerative medicine
    - Department of Public Health and Caring Sciences
      - Caring Sciences
      - Centre for Research Ethics and Bioethics
      - Clinical geriatrics
      - Clinical Nutrition and Metabolism
      - General practice
      - Health Services Research
      - Molecular Geriatrics
      - Public health, working life and rehabilitation
      - Public Health
      - Research in Disability and Habilitation
      - Social medicine/CHAP
      - Speech-Language Pathology
    - Department of Surgical Sciences
      - Anaesthesiology and Intensive Care
        Hedenstierna laboratory
      - Endocrine Surgery
      - Experimental Surgery
      - Forensic Medicine
      - Functional Pharmacology and Neuroscience
      - Medical epidemiology
      - Molecular imaging and medical physics
      - Neuroradiology
      - Nursing Research
      - Odontology & Maxillofacial Surgery
      - Ophthalmic Biophysics
      - Orthopaedics and Handsurgery
      - Otolaryngology and Head and Neck Surgery
      - Pain
      - Plastic Surgery
      - Radiology
      - Thoracic Surgery
      - Transplantation Surgery
      - Upper Abdominal Surgery
      - Urology
      - Vascular Surgery
    - Department of Women's and Children's Health
      - Cardiovascular Psychology
      - CIRCLE – Complex Intervention Research in Health and Care
      - Clinical and translational research in pediatric oncology
      - Clinical Obstetrics
      - International Child Health and Nutrition
      - International Maternal and Reproductive Health and Migration
      - Medical psychology and care science
      - Neuropsychopharmacology
      - Obstetrics and Reproductive Health Research
      - Occupational Therapy
      - Paediatric Inflammation, Metabolism and Child Health Research
      - Participatory eHealth and Health Data Research Group
      - Pediatric oncological and neurological research
      - Pediatric Surgery
      - PERCEPT – Mental Imagery and Mental Health
      - Perinatal, Neonatal and Pediatric Cardiology Research
      - Physiotherapy and behavioral medicine
      - Reproductive biology
      - Reproductive Health
      - SWEDESD - Sustainability Learning and Research Centre
  - Faculty of Pharmacy
    - Department of Medicinal Chemistry
      - Analytical Pharmaceutical Chemistry
      - Chemical Biology for Biomarker Discovery
      - Drug Design and Discovery
      - Farmakognosi
      - Pharmaceutical physical chemistry
      - Preclinical PET-MRI Platform
      - Preparative Medicinal Chemistry
      - Theranostics
      - Translational PET Imaging
    - Department of Pharmaceutical Biosciences
    - Department of Pharmacy
- Disciplinary Domain of Science and Technology
  - Biology
    - Biology Education Centre
      - Klubban Biological Station
      - Swedish Centre for School Biology and Biotechnology
    - Department of Cell and Molecular Biology
      - Computational Biology and Bioinformatics
      - Microbiology and Immunology
      - Molecular Biology
      - Molecular biophysics
      - Molecular Evolution
      - Molecular Systems Biology
      - Structural Biology
    - Department of Ecology and Genetics
      - Animal ecology
      - Evolutionary Biology
      - Limnology
      - Plant Ecology and Evolution
    - Department of Organismal Biology
      - Evolution and Developmental Biology
      - Human Evolution
      - Physiology and Environmental Toxicology
      - Systematic Biology
    - Swedish Biodiversity Centre
  - Chemistry
    - Department of Chemistry - BMC
      - Analytical Chemistry
      - Biochemistry
      - Organic Chemistry
    - Department of Chemistry - Ångström
      - Inorganic Chemistry
      - Macromolecular Chemistry
      - Molecular Biomimetics
      - Physical Chemistry
      - Structural Chemistry
      - Synthetic Molecular Chemistry
  - Earth Sciences
    - Department of Earth Sciences
      - CEMUS
      - Geophysics
      - LUVAL
      - Mineralogy Petrology and Tectonics
      - Natural Resources and Sustainable Development
        Baltic University Programme
        CEMUS Research Forum, CEFO
      - Palaeobiology
      - Uppsala University Sustainability Initiatives (UUSI)
      - Wind Energy
  - Faculty of Science and Technology
  - För teknisk-naturvetenskapliga fakulteten gemensamma enheter
    - International Science Programme (ISP)
    - Tandem Laboratory
  - Mathematics and Computer Science
    - Department of Information Technology
      - Artificial Intelligence
      - Automatic control
      - Computational Science
      - Computer Architecture and Computer Communication
      - Computer Systems
      - Computerized Image Analysis and Human-Computer Interaction
      - Computing Education Research
      - Computing Science
      - Division of Computer Systems
      - Division of Computing Science
      - Division of Scientific Computing
      - Division of Systems and Control
      - Division Vi3
      - Numerical Analysis
    - Department of Mathematics
      - Algebra, Logic and Representation Theory
      - Analysis and Partial Differential Equations
      - Dynamical Systems and Number Theory
      - Geometri and Physics
      - Probability Theory and Combinatorics
      - Statistics, AI and Data Science
  - Physics
    - Department of Physics and Astronomy
      - Applied Nuclear Physics
      - Chemical and Bio-Molecular Physics
      - Condensed Matter Physics of Energy Materials
      - FREIA
      - High Energy Physics
      - Instrumentation and Accelerators
      - Materials Physics
      - Materials Theory
      - Nuclear Physics
      - Observational Astronomy
      - Physics Didactics
      - Quantum Matter Theory
      - Space Plasma Physics
      - The Svedberg Laboratory
      - Theoretical Astrophysics
      - Theoretical Physics
    - Swedish Institute of Space Physics, Uppsala Division
  - Technology
    - Department of Civil and Industrial Engineering
      - Civil Engineering and Built Environment
      - Industrial Engineering and Management
    - Department of Electrical Engineering
      - Electricity
      - Networked Embedded Systems
      - Signals and Systems
      - Solid-State Electronics
    - Department of Materials Science and Engineering
      - Applied Material Science
      - Applied Mechanics
      - Microsystems Technology
        Ångström Space Technology Centre (ÅSTC)
      - Nanotechnology and Functional Materials
      - Solar Cell Technology
      - Solid State Physics
- Music and Museums
  - Museum of Evolution
  - The Linnean Gardens of Uppsala
    - Botanical Garden
  - Uppsala University Museum
    - The Art Collections of the University
    - Uppsala University Coin Cabinet
- National Centre for Knowledge on Men's Violence Against Women
- Science for Life Laboratory, SciLifeLab
  - NBIS - National Bioinformatics Infrastructure Sweden
- Swedish Collegium for Advanced Study (SCAS)
- Units outside the University
  - The Institute for Evaluation of Labour Market and Education Policy (IFAU)
- University Administration
  - Buildings Division
  - Communications Division
  - Division for International Coordination
  - Division for Quality Enhancement
  - Division for Research and Collaboration Support
  - Division of Contract Education
  - Faculty Offices
  - Financial Administration Division
  - Human Resources Division
  - International coordinator
  - IT Division
  - Legal Affairs Division
  - Music and Museums
  - Planning Division
  - Security and safety division
  - Student Affairs and Academic Registry Division
  - Uppsala University Innovation (UU Innovation)
- University Board and Chief Officers
- University Committees
  - Equal Opportunity Committee
- University Library
- Uppsala University Innovation Partnership Office
- WoMHeR (Centre for Women’s Mental Health during the Reproductive Lifespan)

Choose subject

Show subjects that no longer are in use

Agricultural and Veterinary sciences
- Agricultural Biotechnology
  - Genetics and Breeding in Agricultural Sciences
  - Plant Biotechnology
- Agricultural Science, Forestry and Fisheries
  - Agricultural Science
  - Fish and Aquacultural Science
  - Food Science
  - Forest Science
  - Horticulture
  - Landscape Architecture
  - Soil Science
  - Wood Science
- Animal and Dairy Science
- Other Agricultural Sciences
  - Agricultural Occupational Health and Safety
  - Environmental Sciences related to Agriculture and Land-use
  - Fish and Wildlife Management
  - Other Agricultural Sciences not elsewhere specified
  - Renewable Bioenergy Research
- Veterinary Science
  - Clinical Science
  - Medical Bioscience
  - Other Veterinary Science
  - Pathobiology
Engineering and Technology
- Chemical Engineering
  - Chemical Process Engineering
  - Corrosion Engineering
  - Other Chemical Engineering
  - Pharmaceutical Chemistry
  - Polymer Technologies
- Civil Engineering
  - Architectural Engineering
  - Building Technologies
  - Construction Management
  - Environmental Analysis and Construction Information Technology
  - Geotechnical Engineering
  - Infrastructure Engineering
  - Other Civil Engineering
  - Transport Systems and Logistics
  - Water Engineering
- Electrical Engineering, Electronic Engineering, Information Engineering
  - Communication Systems
  - Computer Systems
  - Control Engineering
  - Embedded Systems
  - Other Electrical Engineering, Electronic Engineering, Information Engineering
  - Robotics
  - Signal Processing
  - Telecommunications
- Environmental Biotechnology
  - Bioethics
  - Bioremediation
  - Diagnostic Biotechnology
  - Other Environmental Biotechnology
  - Water Treatment
- Environmental Engineering
  - Energy Systems
  - Environmental Management
  - Geophysical Engineering
  - Marine Engineering
  - Mineral and Mine Engineering
  - Ocean and River Engineering
  - Other Environmental Engineering
  - Remote Sensing
- Industrial Biotechnology
  - Bio Materials
  - Biocatalysis and Enzyme Technology
  - Biochemicals
  - Bioenergy
  - Bioengineering Equipment
  - Bioprocess Technology
  - Medical Biotechnology
  - Other Industrial Biotechnology
  - Pharmaceutical Biotechnology
- Materials Engineering
  - Ceramics
  - Composite Science and Engineering
  - Manufacturing, Surface and Joining Technology
  - Metallurgy and Metallic Materials
  - Other Materials Engineering
  - Paper, Pulp and Fiber Technology
  - Textile, Rubber and Polymeric Materials
- Mechanical Engineering
  - Aerospace Engineering
  - Applied Mechanics
  - Energy Engineering
  - Fluid Mechanics and Acoustics
  - Other Mechanical Engineering
  - Production Engineering, Human Work Science and Ergonomics
  - Reliability and Maintenance
  - Tribology (Interacting Surfaces including Friction, Lubrication and Wear)
  - Vehicle Engineering
- Medical Engineering
  - Medical Equipment Engineering
  - Medical Ergonomics
  - Medical Image Processing
  - Medical Laboratory and Measurements Technologies
  - Medical Materials
  - Other Medical Engineering
- Nano Technology
- Other Engineering and Technologies
  - Food Engineering
  - Interaction Technologies
  - Media Engineering
  - Other Engineering and Technologies not elsewhere specified
Humanities and the Arts
- Arts
  - Architecture
  - Art History
  - Design
  - Literary Composition
  - Music
  - Musicology
  - Performing Art Studies
  - Performing Arts
  - Studies on Film
  - Visual Arts
- History and Archaeology
  - Archaeology
  - History of Technology
  - History
- Languages and Literature
  - General Language Studies and Linguistics
  - General Literature Studies
  - Specific Languages
  - Specific Literatures
- Other Humanities
  - Classical Archaeology and Ancient History
  - Cultural Studies
  - Ethnology
  - Other Humanities not elsewhere specified
- Philosophy, Ethics and Religion
  - Ethics
  - History of Ideas
  - History of Religions
  - Philosophy
  - Religious Studies
Medical and Health Sciences
- Basic Medicine
  - Cell and Molecular Biology
  - Immunology in the medical area
  - Medical Genetics
  - Medicinal Chemistry
  - Microbiology in the medical area
  - Neurosciences
  - Other Basic Medicine
  - Pharmaceutical Sciences
  - Pharmacology and Toxicology
  - Physiology
  - Social and Clinical Pharmacy
- Clinical Medicine
  - Anesthesiology and Intensive Care
  - Cancer and Oncology
  - Cardiac and Cardiovascular Systems
  - Clinical Laboratory Medicine
  - Dentistry
  - Dermatology and Venereal Diseases
  - Endocrinology and Diabetes
  - Gastroenterology and Hepatology
  - General Practice
  - Geriatrics
  - Hematology
  - Infectious Medicine
  - Neurology
  - Obstetrics, Gynecology and Reproductive Medicine
  - Ophthalmology
  - Orthopaedics
  - Other Clinical Medicine
  - Otorhinolaryngology
  - Pediatrics
  - Psychiatry
  - Radiology, Nuclear Medicine and Medical Imaging
  - Respiratory Medicine and Allergy
  - Rheumatology and Autoimmunity
  - Surgery
  - Urology and Nephrology
- Health Sciences
  - Health Care Service and Management, Health Policy and Services and Health Economy
  - Medical Ethics
  - Nursing
  - Nutrition and Dietetics
  - Occupational Health and Environmental Health
  - Occupational Therapy
  - Other Health Sciences
  - Physiotherapy
  - Public Health, Global Health, Social Medicine and Epidemiology
  - Sport and Fitness Sciences
  - Substance Abuse
- Medical Biotechnology
  - Biomaterials Science
  - Biomedical Laboratory Science/Technology
  - Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
  - Other Medical Biotechnology
- Other Medical Sciences
  - Forensic Science
  - Gerontology, specialising in Medical and Health Sciences
  - Other Medical Sciences not elsewhere specified
Natural Sciences
- Biological Sciences
  - Behavioral Sciences Biology
  - Biochemistry and Molecular Biology
  - Bioinformatics and Systems Biology
  - Biological Systematics
  - Biophysics
  - Botany
  - Cell Biology
  - Developmental Biology
  - Ecology
  - Evolutionary Biology
  - Genetics
  - Immunology
  - Microbiology
  - Other Biological Topics
  - Structural Biology
  - Zoology
- Chemical Sciences
  - Analytical Chemistry
  - Inorganic Chemistry
  - Materials Chemistry
  - Organic Chemistry
  - Other Chemistry Topics
  - Physical Chemistry
  - Polymer Chemistry
  - Theoretical Chemistry
- Computer and Information Sciences
  - Bioinformatics (Computational Biology)
  - Computer Engineering
  - Computer Sciences
  - Computer Vision and Robotics (Autonomous Systems)
  - Human Computer Interaction
  - Information Systems
  - Language Technology (Computational Linguistics)
  - Media and Communication Technology
  - Other Computer and Information Science
  - Software Engineering
- Earth and Related Environmental Sciences
  - Climate Research
  - Environmental Sciences
  - Geochemistry
  - Geology
  - Geophysics
  - Geosciences, Multidisciplinary
  - Meteorology and Atmospheric Sciences
  - Oceanography, Hydrology and Water Resources
  - Other Earth and Related Environmental Sciences
  - Physical Geography
- Mathematics
  - Algebra and Logic
  - Computational Mathematics
  - Discrete Mathematics
  - Geometry
  - Mathematical Analysis
  - Other Mathematics
  - Probability Theory and Statistics
- Other Natural Sciences
- Physical Sciences
  - Accelerator Physics and Instrumentation
  - Astronomy, Astrophysics and Cosmology
  - Atom and Molecular Physics and Optics
  - Condensed Matter Physics
  - Fusion, Plasma and Space Physics
  - Other Physics Topics
  - Subatomic Physics
Social Sciences
- Economics and Business
  - Business Administration
  - Economic History
  - Economics
- Educational Sciences
  - Didactics
  - Learning
  - Pedagogical Work
  - Pedagogy
- Law
  - Law (excluding Law and Society)
  - Law and Society
- Media and Communications
  - Communication Studies
  - Human Aspects of ICT
  - Information Studies
  - Information Systems, Social aspects
  - Media Studies
- Other Social Sciences
  - Gender Studies
  - International Migration and Ethnic Relations
  - Other Social Sciences not elsewhere specified
  - Social Sciences Interdisciplinary
  - Work Sciences
- Political Science
  - Globalisation Studies
  - Political Science (excluding Public Administration Studies and Globalisation Studies)
  - Public Administration Studies
- Psychology
  - Applied Psychology
  - Psychology (excluding Applied Psychology)
- Social and Economic Geography
  - Economic Geography
  - Human Geography
- Sociology
  - Social Anthropology
  - Social Psychology
  - Social Work
  - Sociology (excluding Social Work, Social Psychology and Social Anthropology)

Choose research subject

Show research subjects that no longer are in use

Administrative Law
Aesthetics
Applied Mathematics and Statistics
Archaeology
Astronomy and Astrophysics
Astronomy with specialization in Astrophysics
Astronomy
Biblical Exegesis
Biochemistry
Bioinformatics
Biology with Specialisation in Human Evolution and Genetics
Biology with Specialisation in Plant Ecology and Evolution
Biology with specialization in Animal Conservation
Biology with specialization in Animal Development
Biology with specialization in Animal Ecology
Biology with specialization in Comparative Physiology
Biology with specialization in Ecological Botany
Biology with specialization in Environmental Toxicology
Biology with specialization in Evolutionary Functional Genomics
Biology with specialization in Evolutionary Genetics
Biology with specialization in Evolutionary Organismal Biology
Biology with specialization in Limnology
Biology with specialization in Microbiology
Biology with specialization in Molecular Biotechnology
Biology with specialization in Molecular Evolution
Biology with specialization in Population Biology
Biology with specialization in Structural Biology
Biology with specialization in Systematics
Biology
Business Studies
Chemistry with Specialisation in Theoretical Chemistry
Chemistry with specialization in Analytical Chemistry
Chemistry with specialization in Inorganic Chemistry
Chemistry with specialization in Macromolecular Chemistry
Chemistry with specialization in Materials Chemistry
Chemistry with specialization in Microbial Chemistry
Chemistry with specialization in Molecular Biomimetics
Chemistry with specialization in Organic Chemistry
Chemistry with specialization in Physical Chemistry
Chemistry with specialization in Polymer Chemistry
Chemistry
Church History and Mission History
Church History
Civil Law
Classical Archaeology and Ancient History
Computational Linguistics
Computer Science with specialization in Computer Communication
Computer Science with specialization in Computer Science Education Research
Computer Science with specialization in Database Technology
Computer Science with specialization in Embedded Systems
Computer Science with specialization in Human-Computer Interaction
Computer Science
Computerized Image Processing
Computing Education Research
Conservation
Constitutional Law
Corporate Law
Criminal Law
Cultural Anthropology
Curriculum Studies
Domestic Sciences
Earth Science with specialization in Environmental Analysis
Earth Science with specialization in Historical Geology and Palaeontology
Earth Science with specialization in Mineral Chemistry, Petrology and Tectonics
Earth Science with specialization in Physical Geography
Ecclesiology
Economic History
Economics
Education
Egyptology
Electrical Engineering with Specialisation in Networked Embedded Systems
Electrical Engineering with specialization in Automatic Control
Electrical Engineering with specialization in Signal Processing
Empirical-Practical Studies of Religion and Theology
Engineering science with specialization in Applied Mechanics
Engineering Science with specialization in Atmospheric Discharges
Engineering Science with specialization in Biomedical Engineering
Engineering Science with specialization in Civil Engineering and Built Environment
Engineering Science with specialization in Electronics
Engineering Science with specialization in industrial engineering and management
Engineering Science with specialization in Materials Analysis
Engineering Science with specialization in Materials Science
Engineering Science with specialization in Microsystems Technology
Engineering Science with specialization in Microwave Technology
Engineering Science with specialization in Nanotechnology and Functional Materials
Engineering Science with specialization in Science of Electricity
Engineering Science with specialization in Solid Mechanics
Engineering Science with specialization in Solid State Physics
Engineering Science with specialization in Tribo Materials
Engineering Science
English
Environmental Law
Ethics
Ethnology
European (Integration) Law
Finno-Ugric Languages
Fiscal Law
Food, Nutrition and Dietetics
Gender Studies
Geography
Geophysics with specialization in Seismology
Geophysics with specialization in Solid Earth Physics
German
Greek
History of Art
History of Religions and World Christianity
History of Religions
History of Science and Ideas
History of Sciences and Ideas
History
Human-Computer Interaction
Hydrology
Information Systems
Iranian Languages
Jurisprudence
Latin
Legal History and Sociology of Law
Library and Information Science
Linguistics
Literature
Machine learning
Mathematics
Media and Communication Studies
Medical Law
Medical Science
Meteorology
Microbiology
Molecular Life Sciences
Musicology
Natural Resources and Sustainable Development
New Testament Exegesis
Old Testament Exegesis
Peace and Conflict Research
Pharmaceutical Science
Philosophy of Religion
Philosophy, with specialization in history of philosophy
Philosophy
Physics with spec. in Atomic, Molecular and Condensed Matter Physics
Physics with specialization in Applied Nuclear Physics
Physics with specialization in Astrophysics
Physics with specialization in Physics Education
Physics with specialization in Space and Plasma Physics
Physics
Political Science
Practical Philosophy
Private International Law
Procedural Law
Psychology of Religion
Psychology
Public International Law
Public Law
Rhetoric
Romance Languages
Scandinavian Languages
Scientific Computing with specialization in Numerical Analysis
Scientific Computing
Semitic Languages
Sinology
Slavic Languages
Social and Economic Geography
Social Sciences of Religion and Practical Theology
Social Work
Sociology of Education
Sociology of Religion
Sociology
Statistics
Studies of Missions
Systematic Theology and Studies in Worldviews
Systematic Theology
Textile Studies
Theoretical Philosophy
Theoretical Physics
Turkic languages

Select educational program

Show educational programs that no longer are in use

Bachelor of Science Programme in Pharmacy
Bachelor Programme in Behavioural Sciences
Bachelor Programme in Biology / Molecular Biology
Bachelor Programme in Business and Economics
Bachelor Programme in Business Studies
Bachelor Programme in Chemistry
Bachelor Programme in Computer Science
Bachelor Programme in Construction Engineering
Bachelor Programme in Cultural Entrepreneurship
Bachelor Programme in Earth Science
Bachelor Programme in Electrical Engineering
Bachelor Programme in Environmental Science
Bachelor Programme in Foodservice and Nutrition
Bachelor Programme in Historical Sciences
Bachelor Programme in Human Resource Management and Working Life
Bachelor programme in Information Systems
Bachelor Programme in Language Technology
Bachelor Programme in Leadership - Quality Management - Improvement
Bachelor Programme in Liberal Arts
Bachelor Programme in Mathematics
Bachelor Programme in Mechanical Engineering
Bachelor Programme in Musicology
Bachelor Programme in Nuclear Engineering
Bachelor Programme in Oriental Studies
Bachelor Programme in Peace and Development Studies
Bachelor Programme in Physics
Bachelor Programme in Political Science
Bachelor Programme in Quality Engineering and Management
Bachelor Programme in Rhetorical and Literary Communication
Bachelor Programme in Social Sciences
Bachelor Programme in Theology and Religious Studies
Bachelor Programme in Urban and Regional Planning
Bachelor's Programme in Archaeology and Ancient History
Bachelor's Programme in Archaeology and Osteology
Bachelor's Programme in Biomedical Engineering
Bachelor's Programme in Culture, Society and Ethnography
Bachelor's Programme in Digital Business Development
Bachelor's Programme in Energy Transition - Sustainability and Leadership
Bachelor's Programme in Game Design and Graphics
Bachelor's Programme in Game Design and Programming
Bachelor's Programme in Game Design and Project Management
Bachelor's Programme in Game Design
Bachelor's Programme in Media, Communication and Journalism Studies
Bachelor's Programme in Religious Studies
Bachelor's Programme in Sociology
Bachelor's Programme in Sustainable Development in Industrial Engineering
Bachelor's Programme in Theology
Biomedical Laboratory Science Programme
Biomedicine Programme
Building Conservation Program
Business Aministration and Economics Programme
Computer and Systems Science Program
Degree of Master of Science in Speech and Language Pathology
Freestanding course
International Master's Programme in Innovative Medicine
Law Programme
Magisterprogram i revision
Master of Science Programme in Information Technology Engineering
Master of Science Programme in Pharmacy
Master Programme in Accounting, Auditing and Analysis
Master Programme in Advanced Medical Imaging
Master Programme in ALM
Master Programme in Applied Biotechnology
Master Programme in Art History
Master Programme in Bioinformatics
Master Programme in Biology
Master Programme in Biomedicine
Master Programme in Business and Management
Master Programme in Chemical Engineering
Master Programme in Chemistry
Master Programme in Chemistry
Master Programme in Clinical Pharmacy
Master Programme in Computational Science
Master Programme in Computer and Systems Sciences
Master Programme in Computer Science
Master Programme in Computer Science
Master Programme in Conservation
Master Programme in Digital Art History
Master Programme in Drug Discovery and Development
Master Programme in Drug Management
Master Programme in Earth Science
Master Programme in Economics
Master Programme in Education
Master Programme in Educational Management
Master Programme in Educational Sciences
Master Programme in Electrical Engineering
Master Programme in Energy Systems Engineering
Master Programme in Energy Technology
Master Programme in Engineering Physics
Master Programme in Entrepreneurship
Master Programme in Environmental and Water Engineering
Master Programme in Euroculture
Master Programme in Geography
Master Programme in Global Environmental History
Master Programme in Global health
Master Programme in Human Rights
Master Programme in Human-Computer Interaction
Master Programme in Humanitarian Action and Conflict
Master Programme in Industrial Management and Innovation
Master Programme in Infection Biology
Master programme in Information Systems
Master Programme in Intellectual Property Law
Master programme in International Financial Management
Master Programme in International Health
Master Programme in International Humanitarian Action
Master Programme in International Tax Law and EU Tax Law
Master Programme in Investment Treaty Arbitration
Master Programme in Language Technology
Master Programme in Languages
Master Programme in Leadership
Master Programme in Management, Communication and IT
Master Programme in Materials Engineering
Master Programme in Mathematics
Master Programme in Medical Research
Master Programme in Molecular Biotechnology
Master Programme in Peace and Conflict Studies
Master Programme in Physics
Master Programme in Political Science
Master Programme in Politics and International Studies
Master Programme in Public Health
Master Programme in Religion in Peace and Conflict
Master Programme in Renewable Electricity Production
Master Programme in Scandinavian Studies
Master Programme in Social Sciences
Master Programme in Sociology of Education
Master Programme in Statistics
Master Programme in Sustainable Destination Development (120 credits)
Master Programme in Sustainable Destination Development (60 credits)
Master Programme in Sustainable Development
Master Programme in Sustainable Management
Master Programme in Swedish
Master Programme in the Humanities - Art History
Master Programme in the Humanities - Cultural Anthropology
Master Programme in the Humanities - Ethnology
Master Programme in the Humanities - Gender Studies
Master Programme in the Humanities - Literature
Master Programme in the Humanities - Rhetoric
Master Programme in the Humanities – History of Science and Ideas
Master Programme in Theology and Religious Studies
Master Programme in Translation
Master Programme in Wind Power Project Management
Master's Programme in Accounting and Financial Management
Master's Programme in Additive Manufacturing
Master's Programme in All-Electric Propulsion Systems
Master's Programme in Battery Technology and Energy Storage
Master's Programme in Biopharmaceuticals
Master's Programme in Biophysics
Master's Programme in Data Science
Master's Programme in Digital Humanities
Master's Programme in Early Modern History
Master's Programme in Game Design, one year
Master's Programme in Game Design, two years
Master's Programme in Holocaust and Genocide Studies
Master's Programme in Image Analysis and Machine Learning
Master's Programme in Industrial Analytics
Master's Programme in Industrial Engineering and Management
Master's Programme in International and European Law and Business
Master's Programme in Materials Engineering
Master's Programme in Materials Science
Master's Programme in Modern History
Master's Programme in Musicology
Master's Programme in Paleobiology - PANGEA
Master's Programme in Pharmaceutical Modelling
Master's Programme in Pharmaceutical Modelling
Master's Programme in Psychology
Master's Programme in Quantum Technology
Master's Programme in Russian and Eurasian Studies
Master's Programme in Sustainable and Innovative Natural Resource Management - SINReM
Master's programme in the humanities - Cultural Heritage and Sustainability
Master's Programme in Theology and Religious Studies
Master's Programme in Water Engineering
Master's Programme in Wind Power Project Management
Masters Programme in Embedded Systems
Master’s Programme in the Humanities – Archaeology
Master’s Programme in the Humanities – Classical Archaeology and Ancient History
Master’s Programme in the Humanities – Egyptology
Medicine Programme
Midwifery programme
Molecular Biotechnology Engineering Programme
Objects Antiquarian Programme
Open Bachelor's Programme in the Humanities
Physiotherapy programme
Pre-school Teacher Education Programme
Primary School Teacher Education Programme
Programme for Clinical Dietetitians
Programme in Computer Science
Psychotherapy Programme
Psykologprogrammet
Radiography Programme
Registered Nurse Programme
Sjukgymnastprogrammet
Social Work Programme Campus Gotland
Social Work Programme
Special Needs Teacher Education Programme
Specialist Nursing Programme Cardiac Care
Specialist Nursing Programme Diabetes Care
Specialist Nursing Programme Emergency Care
Specialistsjuksköterskeprogrammet med inriktning mot ambulanssjukvård
Specialistsjuksköterskeprogrammet med inriktning mot anestesisjukvård
Specialistsjuksköterskeprogrammet med inriktning mot distriktssköterska
Specialistsjuksköterskeprogrammet med inriktning mot hälso- och sjukvård för barn och ungdomar
Specialistsjuksköterskeprogrammet med inriktning mot intensivvård
Specialistsjuksköterskeprogrammet med inriktning mot kirurgisk vård
Specialistsjuksköterskeprogrammet med inriktning mot onkologisk vård
Specialistsjuksköterskeprogrammet med inriktning mot operationssjukvård
Specialistsjuksköterskeprogrammet med inriktning mot psykiatrisk vård
Specialistsjuksköterskeprogrammet med inriktning mot vård av äldre
Systems in Technology and Society Programme
The Uppsala Culture and Society Programme
Upper Secondary School Teacher Education Programme

Refine search result

1234567 1 - 50 of 318

CiteExportLink to result list

Permanent link

https://uu.diva-portal.org/smash/resultList.jsf?query=&language=en&searchType=ORGANISATION&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all&aq=%5B%5B%7B%22organisationId%22%3A%221378%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&af=%5B%5D

Cite

Citation style

apa
ieee
modern-language-association
vancouver
Other style

More styles

Language

de-DE
en-GB
en-US
fi-FI
nn-NO
nn-NB
sv-SE
Other locale

More languages

Output format

html
text
asciidoc
rtf

Rows per page

Sort

Standard (Relevance)
Author A-Ö
Author Ö-A
Title A-Ö
Title Ö-A
Publication type A-Ö
Publication type Ö-A
Issued (Oldest first)
Issued (Newest first)
Created (Oldest first)
Created (Newest first)
Last updated (Oldest first)
Last updated (Newest first)
Disputation date (earliest first)
Disputation date (latest first)

Standard (Relevance)
Author A-Ö
Author Ö-A
Title A-Ö
Title Ö-A
Publication type A-Ö
Publication type Ö-A
Issued (Oldest first)
Issued (Newest first)
Created (Oldest first)
Created (Newest first)
Last updated (Oldest first)
Last updated (Newest first)
Disputation date (earliest first)
Disputation date (latest first)

Select

The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.

1. Novel genetic loci underlying human intracranial volume identified through genome-wide association
Adams, Hieab H. H.
et al.

Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands..

Hibar, Derrek P.
Univ Southern Calif, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Los Angeles, CA USA..
Chouraki, Vincent
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA.;Univ Lille, RID AGE Risk Factors & Mol Determinants Aging Rel, CHU Lille, Inserm,Inst Pasteur Lille, Lille, France.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA..
Stein, Jason L.
Univ Southern Calif, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Los Angeles, CA USA.;Univ N Carolina, Dept Genet, Chapel Hill, NC USA.;Univ N Carolina, UNC Neurosci Ctr, Chapel Hill, NC USA..
Nyquist, Paul A.
Johns Hopkins Univ, Dept Neurol, Dept Anesthesia Crit Care Med, Dept Neurosurg, Baltimore, MD 21218 USA..
Renteria, Miguel E.
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia..
Trompet, Stella
Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands..
Arias-Vasquez, Alejandro
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
Seshadri, Sudha
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA..
Desrivieres, Sylvane
Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, London, England..
Beecham, Ashley H.
Univ Miami, Miller Sch Med, Dept Human Genet, Dr John T Macdonald Fdn, Miami, FL 33136 USA.;Univ Miami, Miller Sch Med, John P Hussman Inst Human Gen, Miami, FL 33136 USA..
Jahanshad, Neda
Univ Southern Calif, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Los Angeles, CA USA..
Wittfeld, Katharine
German Ctr Neurodegenerat Dis DZNE Rostock Greifs, Greifswald, Germany.;Univ Med Greifswald, Dept Psychiat, Greifswald, Germany..
Van der Lee, Sven J.
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
Abramovic, Lucija
UMC Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands..
Alhusaini, Saud
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ, Canada.;Royal Coll Surgeons Ireland, Dublin 2, Ireland..
Amin, Najaf
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
Andersson, Micael
Umea Univ, Dept Integrat Med Biol, Umea, Sweden.;Umea Univ, Umea Ctr Funct Brain Imaging, Umea, Sweden..
Arfanakis, Konstantinos
IIT, Dept Biomed Engn, Chicago, IL 60616 USA.;Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Dept Diagnost Radiol & Nucl Med, Chicago, IL 60612 USA..
Aribisala, Benjamin S.
Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland.;Lagos State Univ, Dept Comp Sci, Lagos, Nigeria.;Univ Edinburgh, Dept Neuroimaging Sci, Scottish Imaging Network, Edinburgh, Midlothian, Scotland..
Armstrong, Nicola J.
Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.;Murdoch Univ, Math & Stat, Perth, WA, Australia..
Athanasiu, Lavinia
Univ Oslo, Inst Clin Med, NORMENT KG Jebsen Ctr, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT KG Jebsen Ctr, Oslo, Norway..
Axelsson, Tomas
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Beiser, Alexa
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA.;Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA..
Bernard, Manon
Univ Toronto, Hosp Sick Children, Toronto, ON, Canada..
Bis, Joshua C.
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA..
Blanken, Laura M. E.
Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands.;Erasmus MC Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands..
Blanton, Susan H.
Univ Miami, Miller Sch Med, Dept Human Genet, Dr John T Macdonald Fdn, Miami, FL 33136 USA.;Univ Miami, Miller Sch Med, John P Hussman Inst Human Gen, Miami, FL 33136 USA..
Bohlken, Marc M.
UMC Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands..
Boks, Marco P.
UMC Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands..
Bralten, Janita
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
Brickman, Adam M.
Columbia Univ, Med Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA.;Columbia Univ, GH Sergievsky Ctr, Med Ctr, New York, NY USA.;Columbia Univ, Dept Neurol, Med Ctr, New York, NY USA..
Carmichael, Owen
Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA..
Chakravarty, M. Mallar
Douglas Mental Hlth Univ Inst, Cerebral Imaging Ctr, Montreal, PQ, Canada.;McGill Univ, Dept Psychiat & Biomed Engn, Montreal, PQ, Canada..
Chauhan, Ganesh
Univ Bordeaux, INSERM Unit U1219, Bordeaux, France..
Chen, Qiang
Lieber Inst Brain Dev, Baltimore, MD USA..
Ching, Christopher R. K.
Univ Southern Calif, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Los Angeles, CA USA.;Univ Calif Los Angeles, Sch Med, Interdept Neurosci Grad Program, Los Angeles, CA USA..
Cuellar-Partida, Gabriel
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia..
Den Braber, Anouk
Vrije Univ Amsterdam, Biol Psychol, Neurosci Campus Amsterdam, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands..
Doan, Nhat Trung
Univ Oslo, Inst Clin Med, NORMENT KG Jebsen Ctr, Oslo, Norway..
Ehrlich, Stefan
Tech Univ Dresden, Fac Med, Div Psychol & Social Med & Dev Neurosci, Dresden, Germany.;Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA..
Filippi, Irina
Univ Paris Sud, Univ Paris Descartes, NSERM Unit Neuroimaging & Psychiat 1000, Paris, France.;Hosp Cochin, AP HP, Maison Solenn Adolescent Psychopathol & Med Dept, Paris, France..
Ge, Tian
Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA USA.;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Boston, MA USA..
Giddaluru, Sudheer
Univ Bergen, Dept Clin Sci, NORMENT KG Jebsen Ctr Psychosis Res, N-5020 Bergen, Norway.;Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Bergen, Norway..
Goldman, Aaron L.
Lieber Inst Brain Dev, Baltimore, MD USA..
Gottesman, Rebecca F.
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA..
Greven, Corina U.
Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands.;Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands.;Kings Coll London, Med Res Council Social, Genet & Dev Psychiat Ctr, Inst Psychol Psychiat & Neurosci, London, England..
Grimm, Oliver
Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Mannheim, Germany..
Griswold, Michael E.
Univ Mississippi, Med Ctr, Ctr Biostat & Bioinformat, Jackson, MS 39216 USA..
Guadalupe, Tulio
Max Planck Inst Psycholinguist, Language & Genet Dept, Nijmegen, Netherlands.;Int Max Planck Res Sch Language Sci, Nijmegen, Netherlands..
Hass, Johanna
Tech Univ Dresden, Fac Med, Dept Child & Adolescent Psychiat, Dresden, Germany..
Haukvik, Unn K.
Univ Oslo, Inst Clin Med, NORMENT KG Jebsen Ctr, Oslo, Norway.;Diakonhjemmet Hosp, Dept Res & Dev, Oslo, Norway..
Hilal, Saima
Natl Univ Singapore, Dept Pharmacol, Singapore, Singapore.;Natl Univ Hlth Syst, Mem Aging & Cognit Ctr, Singapore, Singapore..
Hofer, Edith
Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, Graz, Austria.;Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria..
Hoehn, David
Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany..
Holmes, Avram J.
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.;Yale Univ, Dept Psychol, New Haven, CT USA..
Hoogman, Martine
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
Janowitz, Deborah
Univ Med Greifswald, Dept Psychiat, Greifswald, Germany..
Jia, Tianye
Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, London, England..
Kasperaviciute, Dalia
UCL, Inst Neurol, London, England.;Epilepsy Soc, Gerrards Cross, Bucks, England.;Imperial Coll London, Dept Med, London, England..
Kim, Sungeun
Indiana Univ, Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN USA.;Indiana Univ, Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN USA..
Klein, Marieke
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
Kraemer, Bernd
Heidelberg Univ, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging, Heidelberg, Germany..
Lee, Phil H.
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA USA.;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Boston, MA USA.;Harvard Med Sch, Massachusetts Gen Hosp, Lurie Ctr Autism, Lexington, MA USA..
Liao, Jiemin
Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore..
Liewald, David C. M.
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland..
Lopez, Lorna M.
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland..
Luciano, Michelle
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland..
Macare, Christine
Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, London, England..
Marquand, Andre
Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Ctr Cognit Neuroimaging, Nijmegen, Netherlands..
Matarin, Mar
UCL, Inst Neurol, London, England.;Epilepsy Soc, Gerrards Cross, Bucks, England.;UCL Inst Neurol, Reta Lila Weston Inst, London, England.;UCL Inst Neurol, Dept Mol Neurosci, London, England..
Mather, Karen A.
Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia..
Mattheisen, Manuel
Aarhus Univ, Dept Biomed, Aarhus, Denmark.;iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark.;iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Copenhagen, Denmark.;Aarhus Univ, iSEQ, Ctr Integrated Sequencing, Aarhus, Denmark..
Mazoyer, Bernard
UMR5296 Univ Bordeaux, CNRS, CEA, Bordeaux, France..
Mckay, David R.
Yale Univ, Dept Psychiat, New Haven, CT 06520 USA.;Olin Neuropsychiat Res Ctr, Hartford, CT USA..
McWhirter, Rebekah
Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia..
Milaneschi, Yuri
VU Univ Med Ctr GGZ Geest, EMGO Inst Hlth & Care Res, Dept Psychiat, Amsterdam, Netherlands.;VU Univ Med Ctr GGZ Geest, Neurosci Campus Amsterdam, Amsterdam, Netherlands..
Mirza-Schreiber, Nazanin
Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany..
Muetzel, Ryan L.
Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands.;Erasmus MC Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands..
Maniega, Susana Munoz
Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Neuroimaging Sci, Scottish Imaging Network, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland..
Nho, Kwangsik
Indiana Univ, Sch Med, Ctr Neuroimaging Radiol & Imaging Sci, Indianapolis, IN USA.;Indiana Univ, Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN USA.;Indiana Univ, Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN USA..
Nugent, Allison C.
NIMH, Exp Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA..
Loohuis, Loes M. Olde
Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA..
Oosterlaan, Jaap
Vrije Univ Amsterdam, Dept Clin Neuropsychol, Amsterdam, Netherlands..
Papmeyer, Martina
Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland.;Univ Bern, Univ Hosp Psychiat, Translat Res Ctr, Div Syst Neurosci Psychopathol, CH-3012 Bern, Switzerland..
Pappa, Irene
Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands.;Erasmus Univ, Sch Pedag & Educ Sci, Rotterdam, Netherlands..
Pirpamer, Lukas
Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, Graz, Austria..
Pudas, Sara
Umea Univ, Dept Integrat Med Biol, Umea, Sweden.;Umea Univ, Umea Ctr Funct Brain Imaging, Umea, Sweden..
Puetz, Benno
Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany..
Rajan, Kumar B.
Rush Univ, Med Ctr, Rush Inst Healthy Aging, Chicago, IL 60612 USA..
Ramasamy, Adaikalavan
UCL Inst Neurol, Reta Lila Weston Inst, London, England.;UCL Inst Neurol, Dept Mol Neurosci, London, England.;Kings Coll London, Dept Med & Mol Genet, London, England.;Univ Oxford, Jenner Inst Labs, Oxford, England..
Richards, Jennifer S.
Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands..
Risacher, Shannon L.
Indiana Univ, Sch Med, Ctr Neuroimaging Radiol & Imaging Sci, Indianapolis, IN USA.;Indiana Univ, Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN USA..
Roiz-Santianez, Roberto
Univ Cantabria IDIVAL, Sch Med, Dept Med & Psychiat, Univ Hosp Marques de Valdecilla, Santander, Spain.;CIBERSAM Ctr Invest Biomed Red Salud Med, Santander, Spain..
Rommelse, Nanda
Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands..
Rose, Emma J.
Trinity Coll Dublin, Psychosis Res Grp, Dept Psychiat, Dublin, Ireland.;Trinity Coll Dublin, Trinity Translat Med Inst, Dublin, Ireland..
Royle, Natalie A.
Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Neuroimaging Sci, Scottish Imaging Network, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland..
Rundek, Tatjana
Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA.;Univ Miami, Miller Sch Med, Dept Epidemiol & Publ Hlth Sci, Miami, FL 33136 USA..
Saemann, Philipp G.
Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany..
Satizabal, Claudia L.
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA..
Schmaal, Lianne
Orygen, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.;Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Neurosci Campus Amsterdam, Amsterdam, Netherlands..
Schork, Andrew J.
Univ Calif San Diego, Dept Neurosci, Multimodal Imaging Lab, San Diego, CA 92103 USA.;Univ Calif San Diego, Dept Cognit Sci, San Diego, CA 92103 USA..
Shen, Li
Indiana Univ, Sch Med, Ctr Neuroimaging Radiol & Imaging Sci, Indianapolis, IN USA.;Indiana Univ, Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN USA.;Indiana Univ, Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN USA..
Shin, Jean
Univ Toronto, Hosp Sick Children, Toronto, ON, Canada..
Shumskaya, Elena
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Ctr Cognit Neuroimaging, Nijmegen, Netherlands..
Smith, Albert V.
Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
Sprooten, Emma
Yale Univ, Dept Psychiat, New Haven, CT 06520 USA.;Olin Neuropsychiat Res Ctr, Hartford, CT USA.;Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland.;Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA..
Strike, Lachlan T.
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia..
Teumer, Alexander
Univ Med Greifswald, Inst Community Med, Greifswald, Germany..
Thomson, Russell

Tordesillas-Gutierrez, Diana
CIBERSAM Ctr Invest Biomed Red Salud Med, Santander, Spain.;Valdecilla Biomed Res Inst IDIVAL, Neuroimaging Unit, Technol Facil, Santander, Cantabria, Spain..
Toro, Roberto
Inst Pasteur, Paris, France..
Trabzuni, Daniah
UCL Inst Neurol, Reta Lila Weston Inst, London, England.;UCL Inst Neurol, Dept Mol Neurosci, London, England.;King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh, Saudi Arabia..
Vaidya, Dhananjay
Johns Hopkins Univ, Sch Med, Dept Med, GeneSTAR Res Ctr, Baltimore, MD 21205 USA..
Van der Grond, Jeroen
Leiden Univ, Med Ctr, Dept Radiol, Leiden, Netherlands..
van der Meer, Dennis
Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands..
Van Donkelaar, Marjolein M. J.
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
Van Eijk, Kristel R.
UMC Utrecht, Human Neurogenet Unit, Brain Ctr Rudolf Magnus, Utrecht, Netherlands..
Van Erp, Theo G. M.
Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA..
Van Rooij, Daan
Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands..
Walton, Esther
Tech Univ Dresden, Fac Med, Dept Child & Adolescent Psychiat, Dresden, Germany..
Westlye, Lars T.
Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT KG Jebsen Ctr, Oslo, Norway.;Univ Oslo, Dept Psychol, NORMENT KG Jebsen Ctr, Oslo, Norway..
Whelan, Christopher D.
Univ Southern Calif, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Los Angeles, CA USA.;Royal Coll Surgeons Ireland, Dublin 2, Ireland..
Windham, Beverly G.
Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA..
Winkler, Anderson M.
Yale Univ, Dept Psychiat, New Haven, CT 06520 USA.;Univ Oxford, FMRIB Ctr, Oxford, England..
Woldehawariat, Girma
NIMH, Exp Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA..
Wolf, Christiane
Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany..
Wolfers, Thomas
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
Xu, Bing
Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, London, England..
Yanek, Lisa R.
Johns Hopkins Univ, Sch Med, Dept Med, GeneSTAR Res Ctr, Baltimore, MD 21205 USA..
Yang, Jingyun
Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA..
Zijdenbos, Alex
Biospect Inc, Montreal, PQ, Canada..
Zwiers, Marcel P.
Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Ctr Cognit Neuroimaging, Nijmegen, Netherlands..
Agartz, Ingrid
Univ Oslo, Inst Clin Med, NORMENT KG Jebsen Ctr, Oslo, Norway.;Diakonhjemmet Hosp, Dept Res & Dev, Oslo, Norway.;Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden..
Aggarwal, Neelum T.
Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Rush Inst Healthy Aging, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA..
Almasy, Laura
Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, San Antonio, TX USA.;Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA.;Childrens Hosp Philadelphia, Dept Biomed & Hlth Informat, Philadelphia, PA 19104 USA..
Ames, David
Royal Melbourne Hosp, Natl Ageing Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Acad Unit Psychiat Old Age, Melbourne, Vic, Australia..
Amouyel, Philippe
Univ Lille, RID AGE Risk Factors & Mol Determinants Aging Rel, CHU Lille, Inserm,Inst Pasteur Lille, Lille, France..
Andreassen, Ole A.
Univ Oslo, Inst Clin Med, NORMENT KG Jebsen Ctr, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT KG Jebsen Ctr, Oslo, Norway..
Arepalli, Sampath
NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA..
Assareh, Amelia A.
Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia..
Barral, Sandra
Columbia Univ, Med Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA..
Bastin, Mark E.
Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Neuroimaging Sci, Scottish Imaging Network, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland..
Becker, Diane M.
Johns Hopkins Univ, Sch Med, Dept Med, GeneSTAR Res Ctr, Baltimore, MD 21205 USA..
Becker, James T.
Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.;Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA.;Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA..
Bennett, David A.
Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA..
Blangero, John
Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, San Antonio, TX USA..
van Bokhoven, Hans
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
Boomsma, Dorret I.
Vrije Univ Amsterdam, Biol Psychol, Neurosci Campus Amsterdam, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands..
Brodaty, Henry
Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.;UNSW, Dementia Collaborat Res Ctr Assessment & Better, Sydney, NSW, Australia..
Brouwer, Rachel M.
UMC Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands..
Brunner, Han G.
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Maastricht Univ, Med Ctr, Dept Clin Genet, Maastricht, Netherlands..
Buckner, Randy L.
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.;Harvard Univ, Dept Psychol, Ctr Brain Sci, 33 Kirkland St, Cambridge, MA 02138 USA..
Buitelaar, Jan K.
Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands..
Bulayeva, Kazima B.
Dagestan State Univ, Dept Evolut & Genet, Makhachkala, Dagestan, Russia..
Cahn, Wiepke
UMC Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands..
Calhoun, Vince D.
Mind Res Network, Albuquerque, NM USA.;LBERI, Albuquerque, NM USA.;Univ New Mexico, Dept ECE, Albuquerque, NM 87131 USA..
Cannon, Dara M.
NIMH, Exp Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.;Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom NICOG, NCBES Galway Neurosci Ctr, Coll Med Nursing & Hlth Sci,Clin Neuroimaging Lab, Galway, Ireland..
Cavalleri, Gianpiero L.
Royal Coll Surgeons Ireland, Dublin 2, Ireland..
Chen, Christopher
Natl Univ Singapore, Dept Pharmacol, Singapore, Singapore.;Natl Univ Hlth Syst, Mem Aging & Cognit Ctr, Singapore, Singapore..
Cheng, Ching -Yu
Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.;Duke NUS Grad Med Sch, Acad Med Res Inst, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore..
Cichon, Sven
Univ Basel, Dept Biomed, Div Med Genet, Basel, Switzerland.;Univ Bonn, Inst Human Genet, Bonn, Germany.;Res Ctr Julich, Inst Neurosci & Med INM1, Julich, Germany..
Cookson, Mark R.
NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA..
Corvin, Aiden
Trinity Coll Dublin, Psychosis Res Grp, Dept Psychiat, Dublin, Ireland.;Trinity Coll Dublin, Trinity Translat Med Inst, Dublin, Ireland..
Crespo-Facorro, Benedicto
Univ Cantabria IDIVAL, Sch Med, Dept Med & Psychiat, Univ Hosp Marques de Valdecilla, Santander, Spain.;CIBERSAM Ctr Invest Biomed Red Salud Med, Santander, Spain..
Curran, Joanne E.
Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, San Antonio, TX USA..
Czisch, Michael
Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany..
Dale, Anders M.
Univ Calif San Diego, Ctr Multimodal Imaging & Genet, San Diego, CA 92103 USA.;Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.;Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA.;Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.;Univ Calif San Diego, Dept Cognit Sci, San Diego, CA 92103 USA..
Davies, Gareth E.
Avera Inst Human Genet, Sioux Falls, SD USA.;Brigham & Womens Hosp, Dept Neurol, Program Translat NeuroPsychiat Gen, 75 Francis St, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Psychiat, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA..
De Geus, Eco J. C.
Vrije Univ Amsterdam, Biol Psychol, Neurosci Campus Amsterdam, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands..
De Jager, Philip L.
Harvard Med Sch, Boston, MA USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Broad Inst, Cambridge, MA USA..
de Zubicaray, Greig I.
Queensland Univ Technol, Fac Hlth, Brisbane, Qld, Australia.;Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia..
Delanty, Norman
Royal Coll Surgeons Ireland, Dublin 2, Ireland.;Beaumont Hosp, Div Neurol, Dublin 9, Ireland..
Depondt, Chantal
Univ Libre Bruxelles, Hop Erasme, Dept Neurol, Brussels, Belgium..
DeStefano, Anita L.
Framingham Heart Dis Epidemiol Study, Framingham, MA USA.;Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Bergen, Norway..
Dillman, Allissa
NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA..
Djurovic, Srdjan
Univ Bergen, Dept Clin Sci, NORMENT KG Jebsen Ctr Psychosis Res, N-5020 Bergen, Norway.;Oslo Univ Hosp, Dept Med Genet, Oslo, Norway..
Donohoe, Gary
Natl Univ Ireland Galway, Cognit Genet & Cognit Therapy Grp, Neuroimaging Cognit & Genom Ctr NICOG, Galway, Ireland.;Natl Univ Ireland Galway, NCBES Galway Neurosci Ctr, Sch Psychol, Galway, Ireland.;Natl Univ Ireland Galway, Discipline Biochem, Galway, Ireland.;Trinity Coll Dublin, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 8, Ireland.;Trinity Coll Dublin, Inst Psychiat, Dublin 8, Ireland..
Drevets, Wayne C.
NIMH, Exp Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.;Janssen Res & Dev LLC, Titusville, NJ USA..
Duggirala, Ravi
Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, San Antonio, TX USA..
Dyer, Thomas D.
Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, San Antonio, TX USA..
Erk, Susanne
Charite, CCM, Dept Psychiat & Psychotherapy, Berlin, Germany..
Espeseth, Thomas
Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT KG Jebsen Ctr, Oslo, Norway.;Univ Oslo, Dept Psychol, NORMENT KG Jebsen Ctr, Oslo, Norway..
Evans, Denis A.
Rush Univ, Med Ctr, Rush Inst Healthy Aging, Chicago, IL 60612 USA..
Fedko, Iryna
Vrije Univ Amsterdam, Biol Psychol, Neurosci Campus Amsterdam, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands..
Fernandez, Guillen
Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
Ferrucci, Luigi
NIA, Intramural Res Program, Baltimore, MD 21224 USA..
Fisher, Simon E.
Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Max Planck Inst Psycholinguist, Language & Genet Dept, Nijmegen, Netherlands..
Fleischman, Debra A.
Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.;Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA..
Ford, Ian
Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland..
Foroud, Tatiana M.
Indiana Univ, Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN USA.;Indiana Univ, Sch Med, Med & Mol Genet, Indianapolis, IN USA..
Fox, Peter T.
Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA..
Francks, Clyde
Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Max Planck Inst Psycholinguist, Language & Genet Dept, Nijmegen, Netherlands..
Fukunaga, Masaki
Natl Inst Physiol Sci, Div Cerebral Integrat, Aichi, Japan..
Gibbs, J. Raphael
UCL Inst Neurol, Reta Lila Weston Inst, London, England.;UCL Inst Neurol, Dept Mol Neurosci, London, England.;NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA..
Glahn, David C.
Yale Univ, Dept Psychiat, New Haven, CT 06520 USA.;Olin Neuropsychiat Res Ctr, Hartford, CT USA..
Gollub, Randy L.
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA.;Harvard Med Sch, Boston, MA USA..
Goring, Harald H. H.
Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Edinburg, TX USA.;Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, San Antonio, TX USA..
Grabe, Hans J.
Univ Med Greifswald, Dept Psychiat, Greifswald, Germany..
Green, Robert C.
Harvard Med Sch, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Div Genet, 75 Francis St, Boston, MA 02115 USA..
Gruber, Oliver
Heidelberg Univ, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging, Heidelberg, Germany..
Gudnason, Vilmundur
Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland..
Guelfi, Sebastian
UCL Inst Neurol, Reta Lila Weston Inst, London, England.;UCL Inst Neurol, Dept Mol Neurosci, London, England..
Hansell, Narelle K.
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia..
Hardy, John
UCL Inst Neurol, Reta Lila Weston Inst, London, England.;UCL Inst Neurol, Dept Mol Neurosci, London, England..
Hartman, Catharina A.
Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands..
Hashimoto, Ryota
Osaka Univ, Grad Sch Med, Dept Psychiat, Osaka, Japan.;Osaka Univ, United Grad Sch Child Dev, Mol Res Ctr Childrens Mental Dev, Osaka, Japan..
Hegenscheid, Katrin
Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol, Greifswald, Germany..
Heinz, Andreas
Charite, CCM, Dept Psychiat & Psychotherapy, Berlin, Germany..
Le Hellard, Stephanie
Univ Bergen, Dept Clin Sci, NORMENT KG Jebsen Ctr Psychosis Res, N-5020 Bergen, Norway.;Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Bergen, Norway..
Hernandez, Dena G.
UCL Inst Neurol, Reta Lila Weston Inst, London, England.;UCL Inst Neurol, Dept Mol Neurosci, London, England.;NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA.;German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany..
Heslenfeld, Dirk J.
Vrije Univ Amsterdam, Dept Psychol, Amsterdam, Netherlands..
Ho, Beng-Choon
Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA..
Hoekstra, Pieter J.
Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands..
Hoffmann, Wolfgang
German Ctr Neurodegenerat Dis DZNE Rostock Greifs, Greifswald, Germany.;Univ Med Greifswald, Inst Community Med, Greifswald, Germany..
Hofman, Albert
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
Holsboer, Florian
Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.;HMNC Brain Hlth, Munich, Germany..
Homuth, Georg
Univ Med Greifswald, Interfac Inst Genet & Funct Gen, Greifswald, Germany..
Hosten, Norbert
Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol, Greifswald, Germany..
Hottenga, Jouke-Jan
Vrije Univ Amsterdam, Biol Psychol, Neurosci Campus Amsterdam, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands..
Pol, Hilleke E. Hulshoff
UMC Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands..
Ikeda, Masashi
Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi, Japan..
Ikram, M. Kamran
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Natl Univ Singapore, Dept Pharmacol, Singapore, Singapore.;Natl Univ Hlth Syst, Mem Aging & Cognit Ctr, Singapore, Singapore.;Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.;Duke NUS Grad Med Sch, Acad Med Res Inst, Singapore, Singapore..
Jack, Clifford R., Jr.
Mayo Clin, Dept Radiol, Rochester, MN USA..
Jenldnson, Mark
Univ Oxford, FMRIB Ctr, Oxford, England..
Johnson, Robert
Univ Maryland, Sch Med, NICHD Brain & Tissue Bank Dev Disorders, Baltimore, MD 21201 USA..
Jonsson, Erik G.
Univ Oslo, Inst Clin Med, NORMENT KG Jebsen Ctr, Oslo, Norway.;Univ Oxford, FMRIB Ctr, Oxford, England..
Jukema, J. Wouter
Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands..
Kahn, Rene S.
UMC Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands..
Kanai, Ryota
Univ Sussex, Sch Psychol, Brighton, E Sussex, England.;UCL, Inst Cognit Neurosci, London, England.;Araya Brain Imaging, Dept Neuroinformat, Tokyo, Japan..
Kloszewska, Iwona
Med Univ Lodz, Lodz, Poland..
Knopman, David S.
Mayo Clin, Dept Neurol, Rochester, MN USA..
Kochunov, Peter
Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21201 USA..
Kwok, John B.
Neurosci Res Australia, Sydney, NSW, Australia.;UNSW, Sch Med Sci, Sydney, NSW, Australia..
Lawrie, Stephen M.
Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland..
Lemaitre, Herve
Univ Paris Sud, Univ Paris Descartes, NSERM Unit Neuroimaging & Psychiat 1000, Paris, France.;Hosp Cochin, AP HP, Maison Solenn Adolescent Psychopathol & Med Dept, Paris, France..
Liu, Xinmin
NIMH, Exp Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.;Columbia Univ, Med Ctr, New York, NY USA..
Longo, Dan L.
NIA, Genet Lab, NIH, Baltimore, MD 21224 USA..
Longstreth, W. T., Jr.
Univ Washington, Dept Neurol, Seattle, WA 98195 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA..
Lopez, Oscar L.
Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA.;Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA..
Lovestone, Simon
Univ Oxford, Dept Psychiat, Oxford, England.;Kings Coll London, NIHR Dementia Biomed Res Unit, London, England..
Martinez, Oliver
Univ Calif Davis, Dept Neurol, Imaging Dementia & Aging IDeA Lab, Sacramento, CA 95817 USA.;Univ Calif Davis, Ctr Neurosci, Sacramento, CA 95817 USA..
Martinot, Jean-Luc
Univ Paris Sud, Univ Paris Descartes, NSERM Unit Neuroimaging & Psychiat 1000, Paris, France.;Hosp Cochin, AP HP, Maison Solenn Adolescent Psychopathol & Med Dept, Paris, France..
Mattay, Venkata S.
Lieber Inst Brain Dev, Baltimore, MD USA.;Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA..
McDonald, Colm
Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom NICOG, NCBES Galway Neurosci Ctr, Coll Med Nursing & Hlth Sci,Clin Neuroimaging Lab, Galway, Ireland..
McIntosh, Andrew M.
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland..
McMahon, Katie L.
Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia..
McMahon, Francis J.
NIMH, Exp Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA..
Mecocci, Patrizia
Univ Perugia, Dept Med, Sect Gerontol & Geriatr, Perugia, Italy..
Melle, Ingrid
Univ Oslo, Inst Clin Med, NORMENT KG Jebsen Ctr, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT KG Jebsen Ctr, Oslo, Norway..
Meyer-Lindenberg, Andreas
Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Mannheim, Germany..
Mohnke, Sebastian
Charite, CCM, Dept Psychiat & Psychotherapy, Berlin, Germany..
Montgomery, Grant W.
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia..
Morris, Derek W.
Natl Univ Ireland Galway, Cognit Genet & Cognit Therapy Grp, Neuroimaging Cognit & Genom Ctr NICOG, Galway, Ireland.;Natl Univ Ireland Galway, NCBES Galway Neurosci Ctr, Sch Psychol, Galway, Ireland.;Natl Univ Ireland Galway, Discipline Biochem, Galway, Ireland.;Trinity Coll Dublin, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 8, Ireland.;Trinity Coll Dublin, Inst Psychiat, Dublin 8, Ireland..
Mosley, Thomas H.
Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA..
Muhleisen, Thomas W.
Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom NICOG, NCBES Galway Neurosci Ctr, Coll Med Nursing & Hlth Sci,Clin Neuroimaging Lab, Galway, Ireland.;Res Ctr Julich, Inst Neurosci & Med INM1, Julich, Germany..
Mueller-Myhsok, Bertram
Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.;Munich Cluster Syst Neurol SyNergy, Munich, Germany.;Univ Liverpool, Inst Translat Med, Liverpool, Merseyside, England..
Nalls, Michael A.
NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA..
Nauck, Matthias
Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.;German Ctr Cardiovasc Res DZHK eV, Partner Site Greifswald, Berlin, Germany..
Nichols, Thomas E.
Univ Oxford, FMRIB Ctr, Oxford, England.;Univ Warwick, Dept Stat, Coventry, W Midlands, England.;Univ Warwick, Warwick Mfg Grp, Coventry, W Midlands, England..
Niessen, Wiro J.
Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands.;Erasmus MC, Dept Med Informat, Rotterdam, Netherlands.;Delft Univ Technol, Fac Sci Appl, Delft, Netherlands..
Noethen, Markus M.
Univ Bonn, Inst Human Genet, Bonn, Germany.;Univ Bonn, Life & Brain Ctr, Dept Genom, Bonn, Germany..
Nyberg, Lars
Umea Univ, Dept Integrat Med Biol, Umea, Sweden.;Umea Univ, Umea Ctr Funct Brain Imaging, Umea, Sweden..
Ohi, Kazutaka
Osaka Univ, Grad Sch Med, Dept Psychiat, Osaka, Japan..
Olvera, Rene L.
Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA..
Ophoff, Roel A.
UMC Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands.;Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA..
Pandolfo, Massimo
Univ Libre Bruxelles, Hop Erasme, Dept Neurol, Brussels, Belgium..
Paus, Tomas
Univ Toronto, Rotman Res Inst, Toronto, ON, Canada.;Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada.;Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada.;Child Mind Inst, New York, NY USA..
Pausova, Zdenka
Univ Toronto, Hosp Sick Children, Toronto, ON, Canada.;Univ Toronto, Dept Phys, Toronto, ON, Canada.;Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada..
Penninx, Brenda W. J. H.
Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Neurosci Campus Amsterdam, Amsterdam, Netherlands..
Pike, G. Bruce
Univ Calgary, Dept Radiol, Calgary, AB, Canada.;Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada..
Potkin, Steven G.
Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA..
Psaty, Bruce M.
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Dept Med, Seattle, WA USA.;Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA.;Grp Hlth Res Inst, Grp Hlth, Seattle, WA USA..
Reppermund, Simone
Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.;UNSW Med, Sch Psychiat, Dept Dev Disabil Neuropsychiat, Kensington, NSW, Australia..
Rietschel, Marcella
Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Mannheim, Germany..
Roffman, Joshua L.
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA..
Romanczuk-Seiferth, Nina
Charite, CCM, Dept Psychiat & Psychotherapy, Berlin, Germany..
Rotter, Jerome I.
Univ Calif Los Angeles, Med Ctr, Ilnst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst & Pediat Harbor, Torrance, CA 90509 USA..
Ryten, Mina
UCL Inst Neurol, Reta Lila Weston Inst, London, England.;UCL Inst Neurol, Dept Mol Neurosci, London, England.;Kings Coll London, Dept Med & Mol Genet, London, England..
Sacco, Ralph L.
Univ Miami, Miller Sch Med, John P Hussman Inst Human Gen, Miami, FL 33136 USA.;Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA.;Univ Miami, Miller Sch Med, Dept Epidemiol & Publ Hlth Sci, Miami, FL 33136 USA.;Univ Miami, Miller Sch Med, Evelyn F McKnight Brain Inst, Miami, FL 33136 USA..
Sachdev, Perminder S.
Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.;Prince Wales Hosp, Neuropsychiat Inst, Sydney, NSW, Australia..
Saykin, Andrew J.
Indiana Univ, Sch Med, Ctr Neuroimaging Radiol & Imaging Sci, Indianapolis, IN USA.;Indiana Univ, Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN USA.;Indiana Univ, Sch Med, Med & Mol Genet, Indianapolis, IN USA..
Schmidt, Reinhold
Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, Graz, Austria..
Schofield, Peter R.
Neurosci Res Australia, Sydney, NSW, Australia.;UNSW, Sch Med Sci, Sydney, NSW, Australia..
Sigurdsson, Sigurdur
Iceland Heart Assoc, Kopavogur, Iceland..
Simmons, Andy
Kings Coll London, Inst Psychiat, Dept Neuroimaging, London, England.;Kings Coll London, Biomed Res Ctr Mental Hlth, London, England.;Kings Coll London, Biomed Res Unit Dementia, London, England..
Singleton, Andrew
NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA..
Sisodiya, Sanjay M.
UCL, Inst Neurol, London, England.;Epilepsy Soc, Gerrards Cross, Bucks, England..
Smith, Colin
Univ Edinburgh, Acad Dept Neuropathol, Ctr Clin Brain Sci, MRC Edinburgh Brain Bank, Edinburgh, Midlothian, Scotland..
Smoller, Jordan W.
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA USA.;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Boston, MA USA..
Soininen, Hindu.
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland.;Kuopio Univ Hosp, Neuroctr Neurol, Kuopio, Finland..
Srikanth, Velandai
Peninsula Hlth & Monash Univ, Dept Med, Melbourne, Vic, Australia..
Steen, Vidar M.
Univ Bergen, Dept Clin Sci, NORMENT KG Jebsen Ctr Psychosis Res, N-5020 Bergen, Norway.;Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Bergen, Norway..
Stott, David J.
Univ Glasgow, Fac Med, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland..
Sussmann, Jessika E.
Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland..
Thalamuthu, Anbupalam
Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia..
Tiemeier, Henning
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands..
Toga, Arthur W.
Univ Southern Calif, Keck Sch Med, Inst Neuroimaging & Informat, Lab Neuro Imaging, Los Angeles, CA USA..
Traynor, Bryan J.
NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA..
Troncoso, Juan
Johns Hopkins Univ, Brain Resource Ctr, Baltimore, MD USA..
Turner, Jessica A.
Georgia State Univ, Atlanta, GA 30303 USA..
Tzourio, Christophe
Univ Bordeaux, Institute Neurodegenerat Disorders, CEA, CNRS,UMR 5293, Bordeaux, France..
Uitterlinden, Andre G.
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Internal Med, Rotterdam, Netherlands..
Hernandez, Maria C. Valdes
Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Neuroimaging Sci, Scottish Imaging Network, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland..
Van der Brug, Marcel
Genentech Inc, San Francisco, CA 94080 USA..
Van der Lugt, Aad
Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands..
Van der Wee, Nic J. A.
Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.;Leiden Univ, Med Ctr, Leiden Inst Brain & Cognit, Leiden, Netherlands..
Van Duijn, Cornelia M.
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands..
Van Haren, Neeltje E. M.
UMC Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands..
Van't Ent, Dennis
Vrije Univ Amsterdam, Biol Psychol, Neurosci Campus Amsterdam, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands..
Van Tol, Marie Jose
Univ Groningen, Univ Med Ctr Groningen, Neuroimaging Ctr, Groningen, Netherlands..
Vardarajan, Badri N.
Columbia Univ, Med Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA..
Veltman, Dick J.
Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Neurosci Campus Amsterdam, Amsterdam, Netherlands..
Vernooij, Meike W.
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands..
Voelzke, Henry
Univ Med Greifswald, Inst Community Med, Greifswald, Germany..
Walter, Henrik
Charite, CCM, Dept Psychiat & Psychotherapy, Berlin, Germany..
Wardlaw, Joanna M.
Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Dept Neuroimaging Sci, Scottish Imaging Network, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland..
Wassink, Thomas H.
Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA..
Weale, Michael E.
Kings Coll London, Dept Med & Mol Genet, London, England..
Weinberger, Daniel R.
Lieber Inst Brain Dev, Baltimore, MD USA.;Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD USA..
Weiner, Michael W.
Univ Calif San Francisco, San Francisco VA Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94143 USA..
Wen, Wei
Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia..
Westman, Eric
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden..
White, Tonya
Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands.;Erasmus MC Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands..
Wong, Tien Y.
Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.;Dagestan State Univ, Dept Evolut & Genet, Makhachkala, Dagestan, Russia.;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore..
Wright, Clinton B.
Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA.;Univ Miami, Miller Sch Med, Dept Epidemiol & Publ Hlth Sci, Miami, FL 33136 USA.;Univ Miami, Miller Sch Med, Evelyn F McKnight Brain Inst, Miami, FL 33136 USA..
Zielke, H. Ronald
Univ Maryland, Sch Med, NICHD Brain & Tissue Bank Dev Disorders, Baltimore, MD 21201 USA..
Zonderman, Alan B.
NIA, Lab Epidemiol & Populat Sci, NIH, Bethesda, MD 20892 USA..
Deary, Ian J.
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol Psychol, Edinburgh, Midlothian, Scotland..
DeCarli, Charles
Univ Calif Davis, Dept Neurol, Imaging Dementia & Aging IDeA Lab, Sacramento, CA 95817 USA.;Univ Calif Davis, Ctr Neurosci, Sacramento, CA 95817 USA..
Schmidt, Helena
Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria..
Martin, Nicholas G.
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia..
De Craen, Anton J. M.
Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands..
Wright, Margaret J.
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.;Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia..
Launer, Lenore J.
NIA, Intramural Res Program, NIH, Bethesda, MD 20892 USA..
Schumann, Gunter
Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC SGDP Ctr, London, England..
Fornage, Myriam
Univ Texas Hlth Sci Ctr Houston, Inst Mol Med & Human Genet Ctr, Houston, TX 77030 USA..
Franke, Barbara
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands..
Debette, Stephanie
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA.;Lieber Inst Brain Dev, Baltimore, MD USA.;Bordeaux Univ Hosp, Dept Neurol, Bordeaux, France..
Medland, Sarah E.
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia..
Ikram, M. Arfan
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands.;Erasmus MC, Dept Neurol, Rotterdam, Netherlands..
Thompson, Paul M.
Univ Southern Calif, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Los Angeles, CA USA.;Univ Western Sydney, Sch Comp Engn & Math, Parramatta, NSW, Australia..
Novel genetic loci underlying human intracranial volume identified through genome-wide association2016In: Nature Neuroscience, ISSN 1097-6256, E-ISSN 1546-1726, Vol. 19, no 12, p. 1569-1582Article in journal (Refereed)
Abstract [en]
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (rho(genetic) = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (N-combined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.
Publisher's full text
2. Allelic expression mapping across cellular lineages to establish impact of non-coding SNPsAdoue, Veronique
et al.

Schiavi, Alicia

Light, Nicholas

Carlsson Almlöf, Jonas
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Lundmark, Per
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Ge, Bing

Kwan, Tony

Caron, Maxime

Rönnblom, Lars
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Wang, Chuan

Chen, Shu-Huang

Goodall, Alison H

Cambien, Francois

Deloukas, Panos

Ouwehand, Willem H

Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Pastinen, Tomi
Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs2014In: Molecular Systems Biology, ISSN 1744-4292, E-ISSN 1744-4292, Vol. 10, no 10, p. 754-Article in journal (Refereed)
Abstract [en]
Most complex disease-associated genetic variants are located in non-coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis-regulatory impact (cis-rSNPs). We used AE mapping to identify cis-rSNPs regulating gene expression in 55 and 63 HapMap lymphoblastoid cell lines from a Caucasian and an African population, respectively, 70 fibroblast cell lines, and 188 purified monocyte samples and found 40-60% of these cis-rSNPs to be shared across cell types. We uncover a new class of cis-rSNPs, which disrupt footprint-derived de novo motifs that are predominantly bound by repressive factors and are implicated in disease susceptibility through overlaps with GWAS SNPs. Finally, we provide the proof-of-principle for a new approach for genome-wide functional validation of transcription factor-SNP interactions. By perturbing NFκB action in lymphoblasts, we identified 489 cis-regulated transcripts with altered AE after NFκB perturbation. Altogether, we perform a comprehensive analysis of cis-variation in four cell populations and provide new tools for the identification of functional variants associated to complex diseases.
Download full text (pdf)
fulltext
Publisher's full text
3. Applications of Four-Colour Fluorescent Primer Extension Technology for SNP Analysis and Discovery
Ahlford, Annika

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Applications of Four-Colour Fluorescent Primer Extension Technology for SNP Analysis and Discovery2010Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]
Studies on genetic variation can reveal effects on traits and disease, both in humans and in model organisms. Good technology for the analysis of DNA sequence variations is critical. Currently the development towards assays for large-scale and parallel DNA sequencing and genotyping is progressing rapidly. Single base primer extension (SBE) is a robust reaction principle based on four-colour fluorescent terminating nucleotides to interrogate all four DNA nucleotides in a single reaction. In this thesis, SBE methods were applied to the analysis and discovery of single nucleotide polymorphism (SNP) in the model organism Drosophila melanogaster and in humans.

The tag-array minisequencing system in a microarray format is convenient for intermediate sized genotyping projects. The system is scalable and flexible to adapt to specialized and novel applications. In Study I of the thesis a tool was established to automate quality control of clustered genotype data. By calculating “Silhouette scores”, the SNP genotype assignment can be evaluated by a single numeric measure. Silhouette scores were then applied in Study I to compare the performance of four DNA polymerases and in Study III to evaluate freeze-dried reagents in the tag-array minisequencing system.

The characteristics of the tag-array minisequencing system makes it suitable for inexpensive genome-wide gene mapping in the fruit fly. In Study II a high-resolution SNP map, and 293 genotyping assays, were established across the X, 2^nd and 3^rd chromosomes to distinguish commonly used Drosophila strains. A database of the SNP markers and a program for automatic allele calling and identification of map positions of mutants was also developed. The utility of the system was demonstrated by rapid mapping of 14 genes that disrupt embryonic muscle patterning.

In Study III the tag-array minisequencing system was adapted to a lab-on-a-chip format for diagnostic testing for mutations in the TP53 gene. Freeze-drying was evaluated for storing reagents, including thermo-sensitive enzymes, on the microchip to reduce the complexity of the integrated test. Correct genotyping results were obtained using freeze-dried reagents in each reaction step of the genotyping protocol, both in test tubes and in single polymer test chambers. The results showed the potential of the approach to be implemented in fully integrated systems.

The four-colour chemistry of SBE has been developed further to allow massively parallel sequencing (MPS) of short DNA fragments as in the Genome Analyzer system (Solexa/Illumina). In Study IV MPS was used to compare Nimblegen arrays and the SureSelect solution-based system for targeted enrichment of 56 continuous human candidate-gene regions totalling 3.1 Mb in size. Both methods detected known SNPs and discovered novel SNPs in the target regions, demonstrating the feasibility for complexity reduction of sequencing libraries by hybridization methods.
List of papers

1.
The record could not be found. The reason may be that the record is no longer available or you may have typed in a wrong id in the address field.

2. High-resolution, high-throughput SNP mapping in Drosophila melanogaster
Open this publication in new window or tab >>High-resolution, high-throughput SNP mapping in Drosophila melanogaster
Chen, Doris
Ahlford, Annika
Schnorrer, Frank
Kalchhauser, Irene
Fellner, Michaela
Viràgh, Erika
Kiss, Istvàn
Syvänen, Ann-Christine
Dickson, Barry J
Show others...
2008 (English)In: Nature Methods, ISSN 1548-7091, E-ISSN 1548-7105, Vol. 5, no 4, p. 323-329Article in journal (Refereed) Published
Abstract [en]
Single nucleotide polymorphisms (SNPs) are useful markers for genetic mapping experiments in model organisms. Here we report the establishment of a high-density SNP map and high-throughput genotyping assays for Drosophila melanogaster. Our map comprises 27,367 SNPs in common laboratory Drosophila stocks. These SNPs were clustered within 2,238 amplifiable markers at an average density of 1 marker every 50.3 kb, or 6.3 genes. We have also constructed a set of 62 Drosophila stocks, each of which facilitates the generation of recombinants within a defined genetic interval of 1-2 Mb. For flexible, high-throughput SNP genotyping, we used fluorescent tag-array mini-sequencing (TAMS) assays. We designed and validated TAMS assays for 293 SNPs at an average resolution of 391.3 kb, and demonstrated the utility of these tools by rapidly mapping 14 mutations that disrupt embryonic muscle patterning. These resources enable high-resolution high-throughput genetic mapping in Drosophila.

Keywords
Animals, Chromosome Mapping, Drosophila melanogaster/embryology/*genetics, Genome; Insect, Muscle Development/*genetics, Mutation, Polymorphism; Single Nucleotide
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-16561 (URN)10.1038/nmeth.1191 (DOI)000254559400019 ()18327265 (PubMedID)

Available from: 2008-05-28 Created: 2008-05-28 Last updated: 2022-01-28Bibliographically approved

3. Positional cloning by fast-track SNP-mapping in Drosophila melanogaster
Open this publication in new window or tab >>Positional cloning by fast-track SNP-mapping in Drosophila melanogaster
Schnorrer, Frank
Ahlford, Annika
Chen, Doris
Milani, Lili
Syvänen, Ann-Christine
Show others...
2008 (English)In: Nature Protocols, ISSN 1754-2189, E-ISSN 1750-2799, Vol. 3, no 11, p. 1751-1765Article in journal (Refereed) Published
Abstract [en]
Positional cloning of chemically induced mutations is the rate-limiting step in forward genetic screens in Drosophila. Single-nucleotide polymorphisms (SNPs) are useful markers to locate a mutated region in the genome. Here, we provide a protocol for high-throughput, high-resolution SNP mapping that enables rapid and cost-effective positional cloning in Drosophila. In stage 1 of the protocol, we use highly multiplexed tag-array mini-sequencing assays to map mutations to an interval of 1-2 Mb. In these assays, SNPs are genotyped by primer extension using fluorescently labeled dideoxy-nucleotides. Fluorescent primers are captured and detected on a microarray. In stage 2, we selectively isolate recombinants within the identified 1-2 Mb interval for fine mapping of mutations to about 50 kb. We have previously demonstrated the applicability of this protocol by mapping 14 muscle morphogenesis mutants within 4 months, which represents a significant acceleration compared with other commonly used mapping strategies that may take years.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-98390 (URN)10.1038/nprot.2008.175 (DOI)000265781600008 ()18948975 (PubMedID)

Available from: 2009-02-20 Created: 2009-02-20 Last updated: 2022-01-28Bibliographically approved

4. Dried reagents for multiplex genotyping by tag-array minisequencing to be used in microfluidic devices
Open this publication in new window or tab >>Dried reagents for multiplex genotyping by tag-array minisequencing to be used in microfluidic devices
Ahlford, Annika
Kjeldsen, Bastian
Reimers, Jakob
Lundmark, Anders
Romani, Massimo
Wolff, Anders
Syvänen, Ann-Christine
Brivio, Monica
Show others...
2010 (English)In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 135, no 9, p. 2377-2385Article in journal (Refereed) Published
Abstract [en]
We present an optimized procedure for freeze-drying and storing reagents for multiplex PCR followed by genotyping using a tag-array minisequencing assay with four color fluorescence detection which is suitable for microfluidic assay formats. A test panel was established for five cancer mutations in three codons (175, 248 and 273) of the tumor protein gene (TP53) and for 13 common single nucleotide polymorphisms (SNPs) in the TP53 gene. The activity of DNA polymerase was preserved for six months of storage after freeze-drying, and the half-life of activities of exonuclease I and shrimp alkaline phosphatase were estimated to 55 and 200 days, respectively. We conducted a systematic genotyping comparison using freeze-dried and liquid reagents. The accuracy of successful genotyping was 99.1% using freeze-dried reagents compared to liquid reagents. As a proof of concept, the genotyping protocol was carried out with freeze-dried reagents stored in reaction chambers fabricated by micromilling in a cyclic olefin copolymer substrate. The results reported in this study are a key step towards the development of an integrated microfluidic device for point-of-care DNA-based diagnostics.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-129216 (URN)10.1039/c0an00321b (DOI)000281007300027 ()20668755 (PubMedID)

Available from: 2010-08-09 Created: 2010-08-09 Last updated: 2022-01-28Bibliographically approved

5.
The record could not be found. The reason may be that the record is no longer available or you may have typed in a wrong id in the address field.

Download full text (pdf)
FULLTEXT01
4. Dried reagents for multiplex genotyping by tag-array minisequencing to be used in microfluidic devices
Ahlford, Annika
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.

Kjeldsen, Bastian

Reimers, Jakob

Lundmark, Anders
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Romani, Massimo

Wolff, Anders

Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Brivio, Monica
Dried reagents for multiplex genotyping by tag-array minisequencing to be used in microfluidic devices2010In: The Analyst, ISSN 0003-2654, E-ISSN 1364-5528, Vol. 135, no 9, p. 2377-2385Article in journal (Refereed)
Abstract [en]
We present an optimized procedure for freeze-drying and storing reagents for multiplex PCR followed by genotyping using a tag-array minisequencing assay with four color fluorescence detection which is suitable for microfluidic assay formats. A test panel was established for five cancer mutations in three codons (175, 248 and 273) of the tumor protein gene (TP53) and for 13 common single nucleotide polymorphisms (SNPs) in the TP53 gene. The activity of DNA polymerase was preserved for six months of storage after freeze-drying, and the half-life of activities of exonuclease I and shrimp alkaline phosphatase were estimated to 55 and 200 days, respectively. We conducted a systematic genotyping comparison using freeze-dried and liquid reagents. The accuracy of successful genotyping was 99.1% using freeze-dried reagents compared to liquid reagents. As a proof of concept, the genotyping protocol was carried out with freeze-dried reagents stored in reaction chambers fabricated by micromilling in a cyclic olefin copolymer substrate. The results reported in this study are a key step towards the development of an integrated microfluidic device for point-of-care DNA-based diagnostics.
Publisher's full text
5. Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance
Alexander, Michelle
et al.

Univ York, York YO10 5DD, N Yorkshire, England.;Univ Aberdeen, Sch Geosci, Dept Archaeol, Aberdeen AB24 3UF, Scotland..

Ho, Simon Y. W.
Univ Sydney, Sch Biol Sci, Sydney, NSW 2006, Australia..
Molak, Martyna
Polish Acad Sci, Museum & Inst Zool, PL-00679 Warsaw, Poland..
Barnett, Ross
Palaeogen & Bioarchaeol Res Network, Res Lab Archaeol, Oxford OX1 3QY, England..
Carlborg, Örjan
Swedish University of Agricultural Sciences, Uppsala, Sweden.
Dorshorst, Ben
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA..
Honaker, Christa
Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA..
Besnier, Francois
Inst Marine Res, Sect Populat Genet, N-5024 Bergen, Norway..
Wahlberg, Per
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Dobney, Keith
Univ Aberdeen, Sch Geosci, Dept Archaeol, Aberdeen AB24 3UF, Scotland..
Siegel, Paul
Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA..
Andersson, Leif
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden..
Larson, Greger
Palaeogen & Bioarchaeol Res Network, Res Lab Archaeol, Oxford OX1 3QY, England..
Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance2015In: Biology Letters, ISSN 1744-9561, E-ISSN 1744-957X, Vol. 11, no 10, article id 20150561Article in journal (Refereed)
Abstract [en]
Mitochondrial genomes represent a valuable source of data for evolutionary research, but studies of their short-term evolution have typically been limited to invertebrates, humans and laboratory organisms. Here we present a detailed study of 12 mitochondrial genomes that span a total of 385 transmissions in a well-documented 50-generation pedigree in which two lineages of chickens were selected for low and high juvenile body weight. These data allowed us to test the hypothesis of time-dependent evolutionary rates and the assumption of strict maternal mitochondrial transmission, and to investigate the role of mitochondrial mutations in determining phenotype. The identification of a non-synonymous mutation in ND4L and a synonymous mutation in CYTB, both novel mutations in Gallus, allowed us to estimate a molecular rate of 3.13 x 10(-7) mutations/site/year (95% confidence interval 3.75 x 10(-8)-1.12 x 10(-6)). This is substantially higher than avian rate estimates based upon fossil calibrations. Ascertaining which of the two novel mutations was present in an additional 49 individuals also revealed an instance of paternal inheritance of mtDNA. Lastly, an association analysis demonstrated that neither of the point mutations was strongly associated with the phenotypic differences between the two selection lines. Together, these observations reveal the highly dynamic nature of mitochondrial evolution over short time periods.
Download full text (pdf)
fulltext
Publisher's full text
6. Genome assembly of the basket willow, <em>Salix viminalis</em>, reveals earliest stages of sex chromosome expansion
Almeida, Pedro
et al.

UCL, Dept Genet Evolut & Environm, London, England.

Proux-Wera, Estelle
Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Stockholm, Sweden.
Churcher, Allison
Umeå Univ, Dept Mol Biol, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Umeå, Sweden.
Soler, Lucile
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Dainat, Jacques
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Pucholt, Pascal
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology. Swedish Univ Agr Sci, Uppsala BioCtr, Linnean Ctr Plant Biol, Dept Plant Biol, Uppsala, Sweden.
Nordlund, Jessica
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Martin, Tom
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Uppsala University, Science for Life Laboratory, SciLifeLab.
Rönnberg-Wästljung, Ann-Christin
Swedish Univ Agr Sci, Uppsala BioCtr, Linnean Ctr Plant Biol, Dept Plant Biol, Uppsala, Sweden.
Nystedt, Björn
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
Berlin, Sofia
Swedish Univ Agr Sci, Uppsala BioCtr, Linnean Ctr Plant Biol, Dept Plant Biol, Uppsala, Sweden.
Mank, Judith E.
UCL, Dept Genet Evolut & Environm, London, England; Univ British Columbia, Dept Zool, Vancouver, BC, Canada; Univ British Columbia, Biodivers Res Ctr, Vancouver, BC, Canada.
Genome assembly of the basket willow, Salix viminalis, reveals earliest stages of sex chromosome expansion2020In: BMC Biology, E-ISSN 1741-7007, Vol. 18, no 1, article id 78Article in journal (Refereed)
Abstract [en]
Background
Sex chromosomes have evolved independently multiple times in eukaryotes and are therefore considered a prime example of convergent genome evolution. Sex chromosomes are known to emerge after recombination is halted between a homologous pair of chromosomes, and this leads to a range of non-adaptive modifications causing gradual degeneration and gene loss on the sex-limited chromosome. However, the proximal causes of recombination suppression and the pace at which degeneration subsequently occurs remain unclear.
Results
Here, we use long- and short-read single-molecule sequencing approaches to assemble and annotate a draft genome of the basket willow, Salix viminalis, a species with a female heterogametic system at the earliest stages of sex chromosome emergence. Our single-molecule approach allowed us to phase the emerging Z and W haplotypes in a female, and we detected very low levels of Z/W single-nucleotide divergence in the non-recombining region. Linked-read sequencing of the same female and an additional male (ZZ) revealed the presence of two evolutionary strata supported by both divergence between the Z and W haplotypes and by haplotype phylogenetic trees. Gene order is still largely conserved between the Z and W homologs, although the W-linked region contains genes involved in cytokinin signaling regulation that are not syntenic with the Z homolog. Furthermore, we find no support across multiple lines of evidence for inversions, which have long been assumed to halt recombination between the sex chromosomes.
Conclusions
Our data suggest that selection against recombination is a more gradual process at the earliest stages of sex chromosome formation than would be expected from an inversion and may result instead from the accumulation of transposable elements. Our results present a cohesive understanding of the earliest genomic consequences of recombination suppression as well as valuable insights into the initial stages of sex chromosome formation and regulation of sex differentiation.
Download full text (pdf)
FULLTEXT01
Publisher's full text
7. Powerful Identification of Cis-regulatory SNPs in Human Primary Monocytes Using Allele-Specific Gene Expression
Almlöf, Jonas Carlsson
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.

Lundmark, Per
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Lundmark, Anders
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Ge, B.

Maouche, S.

Göring, H. H. H.

Liljedahl, Ulrika
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Enström, Camilla
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Brocheton, J.

Proust, C.

Godefroy, T.

Sambrook, J. G.

Jolley, J.

Crisp-Hihn, A.

Foad, N.

Lloyd-Jones, H.

Stephens, J.

Gwilliam, R.

Rice, C. M.

Hengstenberg, C.

Samani, N. J.

Erdmann, J.

Schunkert, H.

Pastinen, T.

Deloukas, P.

Goodall, A. H.

Ouwehand, W. H.

Cambien, F.

Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Powerful Identification of Cis-regulatory SNPs in Human Primary Monocytes Using Allele-Specific Gene Expression2012In: PLOS ONE, E-ISSN 1932-6203, Vol. 7, no 12, p. e52260-Article in journal (Refereed)
Abstract [en]
A large number of genome-wide association studies have been performed during the past five years to identify associations between SNPs and human complex diseases and traits. The assignment of a functional role for the identified disease-associated SNP is not straight-forward. Genome-wide expression quantitative trait locus (eQTL) analysis is frequently used as the initial step to define a function while allele-specific gene expression (ASE) analysis has not yet gained a wide-spread use in disease mapping studies. We compared the power to identify cis-acting regulatory SNPs (cis-rSNPs) by genome-wide allele-specific gene expression (ASE) analysis with that of traditional expression quantitative trait locus (eQTL) mapping. Our study included 395 healthy blood donors for whom global gene expression profiles in circulating monocytes were determined by Illumina BeadArrays. ASE was assessed in a subset of these monocytes from 188 donors by quantitative genotyping of mRNA using a genome-wide panel of SNP markers. The performance of the two methods for detecting cis-rSNPs was evaluated by comparing associations between SNP genotypes and gene expression levels in sample sets of varying size. We found that up to 8-fold more samples are required for eQTL mapping to reach the same statistical power as that obtained by ASE analysis for the same rSNPs. The performance of ASE is insensitive to SNPs with low minor allele frequencies and detects a larger number of significantly associated rSNPs using the same sample size as eQTL mapping. An unequivocal conclusion from our comparison is that ASE analysis is more sensitive for detecting cis-rSNPs than standard eQTL mapping. Our study shows the potential of ASE mapping in tissue samples and primary cells which are difficult to obtain in large numbers.
Download full text (pdf)
fulltext
Publisher's full text
8. Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
Almlöf, Jonas Carlsson
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.

Nystedt, Sara
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Leonard, Dag
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Eloranta, Maija-Leena
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Grosso, Giorgia
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit,Rheumatol, S-17177 Stockholm, Sweden.
Sjowall, Christopher
Linkoping Univ, Div Neuro & Inflammat Sci, Dept Clin & Expt Med, Rheumatol, S-58183 Linkoping, Sweden.
Bengtsson, Anders A.
Lund Univ, Skane Univ Hosp, Dept Clin Sci, Rheumatol, S-22242 Lund, Sweden.
Jonsen, Andreas
Lund Univ, Skane Univ Hosp, Dept Clin Sci, Rheumatol, S-22242 Lund, Sweden.
Gunnarsson, Iva
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit,Rheumatol, S-17177 Stockholm, Sweden.
Svenungsson, Elisabet
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit,Rheumatol, S-17177 Stockholm, Sweden.
Rönnblom, Lars
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Sandling, Johanna K.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus2019In: Human Genetics, ISSN 0340-6717, E-ISSN 1432-1203, Vol. 138, no 2, p. 141-150Article in journal (Refereed)
Abstract [en]
Systemic lupus erythematosus (SLE, OMIM 152700) is a systemic autoimmune disease with a complex etiology. The mode of inheritance of the genetic risk beyond familial SLE cases is currently unknown. Additionally, the contribution of heterozygous variants in genes known to cause monogenic SLE is not fully understood. Whole-genome sequencing of DNA samples from 71 Swedish patients with SLE and their healthy biological parents was performed to investigate the general genetic risk of SLE using known SLE GWAS risk loci identified using the ImmunoChip, variants in genes associated to monogenic SLE, and the mode of inheritance of SLE risk alleles in these families. A random forest model for predicting genetic risk for SLE showed that the SLE risk variants were mainly inherited from one of the parents. In the 71 patients, we detected a significant enrichment of ultra-rare (0.1%) missense and nonsense mutations in 22 genes known to cause monogenic forms of SLE. We identified one previously reported homozygous nonsense mutation in the C1QC (Complement C1q C Chain) gene, which explains the immunodeficiency and severe SLE phenotype of that patient. We also identified seven ultra-rare, coding heterozygous variants in five genes (C1S, DNASE1L3, DNASE1, IFIH1, and RNASEH2A) involved in monogenic SLE. Our findings indicate a complex contribution to the overall genetic risk of SLE by rare variants in genes associated with monogenic forms of SLE. The rare variants were inherited from the other parent than the one who passed on the more common risk variants leading to an increased genetic burden for SLE in the child. Higher frequency SLE risk variants are mostly passed from one of the parents to the offspring affected with SLE. In contrast, the other parent, in seven cases, contributed heterozygous rare variants in genes associated with monogenic forms of SLE, suggesting a larger impact of rare variants in SLE than hitherto reported.
Download full text (pdf)
fulltext
Publisher's full text
9. Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes
Almlöf, Jonas
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.

Lundmark, Per
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Lundmark, Anders
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Ge, Bing

Pastinen, Tomi

Goodall, Alison H

Cambien, François

Deloukas, Panos

Ouwehand, Willem H

Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes2014In: PLOS ONE, E-ISSN 1932-6203, Vol. 9, no 7, p. e102612-Article in journal (Refereed)
Abstract [en]
We applied genome-wide allele-specific expression analysis of monocytes from 188 samples. Monocytes were purified from white blood cells of healthy blood donors to detect cis-acting genetic variation that regulates the expression of long non-coding RNAs. We analysed 8929 regions harboring genes for potential long non-coding RNA that were retrieved from data from the ENCODE project. Of these regions, 60% were annotated as intergenic, which implies that they do not overlap with protein-coding genes. Focusing on the intergenic regions, and using stringent analysis of the allele-specific expression data, we detected robust cis-regulatory SNPs in 258 out of 489 informative intergenic regions included in the analysis. The cis-regulatory SNPs that were significantly associated with allele-specific expression of long non-coding RNAs were enriched to enhancer regions marked for active or bivalent, poised chromatin by histone modifications. Out of the lncRNA regions regulated by cis-acting regulatory SNPs, 20% (n = 52) were co-regulated with the closest protein coding gene. We compared the identified cis-regulatory SNPs with those in the catalog of SNPs identified by genome-wide association studies of human diseases and traits. This comparison identified 32 SNPs in loci from genome-wide association studies that displayed a strong association signal with allele-specific expression of non-coding RNAs in monocytes, with p-values ranging from 6.7×10-7 to 9.5×10-89. The identified cis-regulatory SNPs are associated with diseases of the immune system, like multiple sclerosis and rheumatoid arthritis.
Download full text (pdf)
fulltext
Publisher's full text
10. De Novo Assembly of Two Swedish Genomes Reveals Missing Segments from the Human GRCh38 Reference and Improves Variant Calling of Population-Scale Sequencing Data
Ameur, Adam
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.

Che, Huiwen
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Martin, Marcel
Stockholm Univ, DBB, Sci Life Lab, S-11419 Stockholm, Sweden.
Bunikis, Ignas
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, S-75236 Uppsala, Sweden.
Dahlberg, Johan
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Höijer, Ida
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Häggqvist, Susana
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Vezzi, Francesco
Stockholm Univ, DBB, Sci Life Lab, S-11419 Stockholm, Sweden.
Nordlund, Jessica
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala Univ, Dept Med Sci, Sci Life Lab, Mol Med, S-75236 Uppsala, Sweden.
Olason, Pall
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
Feuk, Lars
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
Gyllensten, Ulf B.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
De Novo Assembly of Two Swedish Genomes Reveals Missing Segments from the Human GRCh38 Reference and Improves Variant Calling of Population-Scale Sequencing Data2018In: Genes, E-ISSN 2073-4425, Vol. 9, no 10, article id 486Article in journal (Refereed)
Abstract [en]
The current human reference sequence (GRCh38) is a foundation for large-scale sequencing projects. However, recent studies have suggested that GRCh38 may be incomplete and give a suboptimal representation of specific population groups. Here, we performed a de novo assembly of two Swedish genomes that revealed over 10 Mb of sequences absent from the human GRCh38 reference in each individual. Around 6 Mb of these novel sequences (NS) are shared with a Chinese personal genome. The NS are highly repetitive, have an elevated GC-content, and are primarily located in centromeric or telomeric regions. Up to 1 Mb of NS can be assigned to chromosome Y, and large segments are also missing from GRCh38 at chromosomes 14, 17, and 21. Inclusion of NS into the GRCh38 reference radically improves the alignment and variant calling from short-read whole-genome sequencing data at several genomic loci. A re-analysis of a Swedish population-scale sequencing project yields > 75,000 putative novel single nucleotide variants (SNVs) and removes > 10,000 false positive SNV calls per individual, some of which are located in protein coding regions. Our results highlight that the GRCh38 reference is not yet complete and demonstrate that personal genome assemblies from local populations can improve the analysis of short-read whole-genome sequencing data.
Download full text (pdf)
FULLTEXT01
Publisher's full text
11. SweGen
Ameur, Adam
et al.

Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Natl Genom Infrastruct, Sci Life Lab, Stockholm, Sweden..

Dahlberg, Johan
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Natl Genom Infrastruct, Sci Life Lab, Stockholm, Sweden.
Olason, Pall
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. Natl Bioinformat Infrastruct, Sci Life Lab, Stockholm, Sweden..
Vezzi, Francesco
Natl Genom Infrastruct, Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
Karlsson, Robert
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
Martin, Marcel
Natl Bioinformat Infrastruct, Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
Viklund, Johan
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics. Natl Bioinformat Infrastruct, Sci Life Lab, Stockholm, Sweden..
Kähäri, Andreas
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics. Natl Bioinformat Infrastruct, Sci Life Lab, Stockholm, Sweden..
Lundin, Par
Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
Che, Huiwen
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Thutkawkorapin, Jessada
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
Eisfeldt, Jesper
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
Lampa, Samuel
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Natl Bioinformat Infrastruct, Sci Life Lab, Stockholm, Sweden.
Dahlberg, Mats
Natl Bioinformat Infrastruct, Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
Hagberg, Jonas
Natl Bioinformat Infrastruct, Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
Jareborg, Niclas
Natl Bioinformat Infrastruct, Sci Life Lab, Stockholm, Sweden.;Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden..
Liljedahl, Ulrika
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Natl Genom Infrastruct, Sci Life Lab, Stockholm, Sweden.
Jonasson, Inger
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Natl Genom Infrastruct, Sci Life Lab, Stockholm, Sweden..
Johansson, Åsa
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
Feuk, Lars
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
Lundeberg, Joakim
Natl Genom Infrastruct, Sci Life Lab, Stockholm, Sweden.;Royal Inst Technol, Div Gene Technol, Sch Biotechnol, Sci Life Lab, Stockholm, Sweden..
Syvänen, Ann-Christine
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Natl Genom Infrastruct, Sci Life Lab, Stockholm, Sweden.
Lundin, Sverker
Royal Inst Technol, Div Gene Technol, Sch Biotechnol, Sci Life Lab, Stockholm, Sweden..
Nilsson, Daniel
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
Nystedt, Björn
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Evolution. Natl Bioinformat Infrastruct, Sci Life Lab, Stockholm, Sweden..
Magnusson, Patrik K. E.
Natl Genom Infrastruct, Sci Life Lab, Stockholm, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
Gyllensten, Ulf B.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
SweGen: a whole-genome data resource of genetic variability in a cross-section of the Swedish population2017In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 25, no 11, p. 1253-1260Article in journal (Refereed)
Abstract [en]
Here we describe the SweGen data set, a comprehensive map of genetic variation in the Swedish population. These data represent a basic resource for clinical genetics laboratories as well as for sequencing-based association studies by providing information on genetic variant frequencies in a cohort that is well matched to national patient cohorts. To select samples for this study, we first examined the genetic structure of the Swedish population using high-density SNP-array data from a nation-wide cohort of over 10 000 Swedish-born individuals included in the Swedish Twin Registry. A total of 1000 individuals, reflecting a cross-section of the population and capturing the main genetic structure, were selected for whole-genome sequencing. Analysis pipelines were developed for automated alignment, variant calling and quality control of the sequencing data. This resulted in a genome-wide collection of aggregated variant frequencies in the Swedish population that we have made available to the scientific community through the website https://swefreq.nbis.se. A total of 29.2 million single-nucleotide variants and 3.8 million indels were detected in the 1000 samples, with 9.9 million of these variants not present in current databases. Each sample contributed with an average of 7199 individual-specific variants. In addition, an average of 8645 larger structural variants (SVs) were detected per individual, and we demonstrate that the population frequencies of these SVs can be used for efficient filtering analyses. Finally, our results show that the genetic diversity within Sweden is substantial compared with the diversity among continental European populations, underscoring the relevance of establishing a local reference data set.
Download full text (pdf)
fulltext
Publisher's full text
12. Cerebrospinal fluid monoamine metabolite concentrations as intermediate phenotypes between glutamate-related genes and psychosis
Andreou, Dimitrios
et al.

Karolinska Hosp & Inst, Dept Clin Neurosci, Psychiat Sect, HUBIN Project, Stockholm, Sweden..

Soderman, Erik
Karolinska Hosp & Inst, Dept Clin Neurosci, Psychiat Sect, HUBIN Project, Stockholm, Sweden..
Axelsson, Tomas
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Sedvall, Goran C.
Karolinska Hosp & Inst, Dept Clin Neurosci, Psychiat Sect, HUBIN Project, Stockholm, Sweden..
Terenius, Lars
Karolinska Hosp & Inst, Dept Clin Neurosci, Psychiat Sect, HUBIN Project, Stockholm, Sweden..
Agartz, Ingrid
Karolinska Hosp & Inst, Dept Clin Neurosci, Psychiat Sect, HUBIN Project, Stockholm, Sweden.;Univ Oslo, NORMENT, Inst Clin Med, Oslo, Norway.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway..
Jonsson, Erik G.
Karolinska Hosp & Inst, Dept Clin Neurosci, Psychiat Sect, HUBIN Project, Stockholm, Sweden.;Univ Oslo, NORMENT, Inst Clin Med, Oslo, Norway..
Cerebrospinal fluid monoamine metabolite concentrations as intermediate phenotypes between glutamate-related genes and psychosis2015In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 229, no 1-2, p. 497-504Article in journal (Refereed)
Abstract [en]
Glutamate-related genes have been associated with schizophrenia, but the results have been ambiguous and difficult to replicate. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are the major degradation products of the monoamines dopamine, serotonin and noradrenaline, respectively, and their concentrations in the cerebrospinal fluid (CSF), mainly HVA, have been associated with schizophrenia. In the present study, we hypothesized that CSF HVA, 5-HIAA and MHPG concentrations represent intermediate phenotypes in the association between glutamate-related genes and psychosis. To test this hypothesis, we searched for association between 238 single nucleotide polymorphisms (SNPs) in ten genes shown to be directly or indirectly implicated in glutamate transmission and CSF HVA, 5-HIAA and MHPG concentrations in 74 patients with psychotic disease. Thirty-eight nominally significant associations were found. Further analyses in 111 healthy controls showed that 87% of the nominal associations were restricted to the patients with psychosis. Some of the psychosis-only-associated SNPs found in the D-amino acid oxidase activator (DADA) and the kynurenine 3-monooxygenase (KMO) genes have previously been reported to be associated with schizophrenia. The present results suggest that CSF monoamine metabolite concentrations may represent intermediate phenotypes in the association between glutamate-related genes and psychosis.
Download full text (pdf)
fulltext
Publisher's full text
13. Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosisAndreou, Dimitrios
et al.

Söderman, Erik

Axelsson, Tomas
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Sedvall, Göran C

Terenius, Lars

Agartz, Ingrid

Jönsson, Erik G
Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis2014In: Behavioral and Brain Functions, E-ISSN 1744-9081, Vol. 10, p. 26-Article in journal (Refereed)
Abstract [en]
BACKGROUND: Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are the major monoamine metabolites in the central nervous system (CNS). Their cerebrospinal fluid (CSF) concentrations, reflecting the monoamine turnover rates in CNS, are partially under genetic influence and have been associated with schizophrenia. We have hypothesized that CSF monoamine metabolite concentrations represent intermediate steps between single nucleotide polymorphisms (SNPs) in genes implicated in monoaminergic pathways and psychosis.
METHODS: We have searched for association between 119 SNPs in genes implicated in monoaminergic pathways [tryptophan hydroxylase 1 (TPH1), TPH2, tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), catechol-O-methyltransferase (COMT), monoamine oxidase A (MAOA) and MAOB] and monoamine metabolite concentrations in CSF in 74 patients with psychotic disorder.
RESULTS: There were 42 nominally significant associations between SNPs and CSF monoamine metabolite concentrations, which exceeded the expected number (20) of nominal associations given the total number of tests performed. The strongest association (p = 0.0004) was found between MAOB rs5905512, a SNP previously reported to be associated with schizophrenia in men, and MHPG concentrations in men with psychotic disorder. Further analyses in 111 healthy individuals revealed that 41 of the 42 nominal associations were restricted to patients with psychosis and were absent in healthy controls.
CONCLUSIONS: The present study suggests that altered monoamine turnover rates in CNS reflect intermediate steps in the associations between SNPs and psychosis.
Download full text (pdf)
fulltext
Publisher's full text
14. A microarray system for Y chromosomal and mitochondrial single nucleotide polymorphism analysis in chimpanzee populationsAndres, Olga
et al.

Rönn, Ann-Charlotte
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Bonhomme, Maxime

Keller-Mann, Thomas

Crouau-Roy, Brigitte

Doxiadis, Gaby

Verschoor, Ernst J.

Goossens, Benoit

Domingo-Roura, Xavier

Bruford, Michael W.

Bosch, Montserrat

Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
A microarray system for Y chromosomal and mitochondrial single nucleotide polymorphism analysis in chimpanzee populations2008In: Molecular Ecology Notes, ISSN 1471-8278, E-ISSN 1471-8286, Vol. 8, no 3, p. 529-539Article in journal (Refereed)
Abstract [en]
Chimpanzee populations are diminishing as a consequence of human activities, and as a result this species is now endangered. In the context of conservation programmes, genetic data can add vital information, for instance on the genetic diversity and structure of threatened populations. Single nucleotide polymorphisms (SNP) are biallelic markers that are widely used in human molecular studies and can be implemented in efficient microarray systems. This technology offers the potential of robust, multiplexed SNP genotyping at low reagent cost in other organisms than humans, but it is not commonly used yet in wild population studies. Here, we describe the characterization of new SNPs in Y-chromosomal intronic regions in chimpanzees and also identify SNPs from mitochondrial genes, with the aim of developing a microarray system that permits the simultaneous study of both paternal and maternal lineages. Our system consists of 42 SNPs for the Y chromosome and 45 SNPs for the mitochondrial genome. We demonstrate the applicability of this microarray in a captive population where genotypes accurately reflected its large pedigree. Two wild-living populations were also analysed and the results show that the microarray will be a useful tool alongside microsatellite markers, since it supplies complementary information about population structure and ecology. SNP genotyping using microarray technology, therefore, is a promising approach and may become an essential tool in conservation genetics to help in the management and study of captive and wild-living populations. Moreover, microarrays that combine SNPs from different genomic regions could replace microsatellite typing in the future.
Publisher's full text
15. Sequence quality is maintained after multiple displacement amplification of non-invasively obtained macaque semen DNAAndrés, Olga
et al.

Rönn, Ann-Charlotte
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Ferrando, Aïnhoa

Bosch, Montserrat

Domingo-Roura, Xavier
Sequence quality is maintained after multiple displacement amplification of non-invasively obtained macaque semen DNA2006In: Biotechnology Journal, ISSN 1860-7314, Vol. 1, no 4, p. 466-469Article in journal (Refereed)
16. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.Arking, Dan E
et al.

Pulit, Sara L

Crotti, Lia

van der Harst, Pim

Munroe, Patricia B

Koopmann, Tamara T

Sotoodehnia, Nona

Rossin, Elizabeth J

Morley, Michael

Wang, Xinchen

Johnson, Andrew D

Lundby, Alicia

Gudbjartsson, Daníel F

Noseworthy, Peter A

Eijgelsheim, Mark

Bradford, Yuki

Tarasov, Kirill V

Dörr, Marcus

Müller-Nurasyid, Martina

Lahtinen, Annukka M

Nolte, Ilja M

Smith, Albert Vernon

Bis, Joshua C

Isaacs, Aaron

Newhouse, Stephen J

Evans, Daniel S

Post, Wendy S

Waggott, Daryl

Lyytikäinen, Leo-Pekka

Hicks, Andrew A

Eisele, Lewin

Ellinghaus, David

Hayward, Caroline

Navarro, Pau

Ulivi, Sheila

Tanaka, Toshiko

Tester, David J

Chatel, Stéphanie

Gustafsson, Stefan
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Kumari, Meena

Morris, Richard W

Naluai, Asa T

Padmanabhan, Sandosh

Kluttig, Alexander

Strohmer, Bernhard

Panayiotou, Andrie G

Torres, Maria

Knoflach, Michael

Hubacek, Jaroslav A

Slowikowski, Kamil

Raychaudhuri, Soumya

Kumar, Runjun D

Harris, Tamara B

Launer, Lenore J

Shuldiner, Alan R

Alonso, Alvaro

Bader, Joel S

Ehret, Georg

Huang, Hailiang

Kao, W H Linda

Strait, James B

Macfarlane, Peter W

Brown, Morris

Caulfield, Mark J

Samani, Nilesh J

Kronenberg, Florian

Willeit, Johann

Smith, J Gustav

Greiser, Karin H

Meyer Zu Schwabedissen, Henriette

Werdan, Karl

Carella, Massimo

Zelante, Leopoldo

Heckbert, Susan R

Psaty, Bruce M

Rotter, Jerome I

Kolcic, Ivana

Polašek, Ozren

Wright, Alan F

Griffin, Maura

Daly, Mark J

Arnar, David O

Hólm, Hilma

Thorsteinsdottir, Unnur

Denny, Joshua C

Roden, Dan M

Zuvich, Rebecca L

Emilsson, Valur

Plump, Andrew S

Larson, Martin G

O'Donnell, Christopher J

Yin, Xiaoyan

Bobbo, Marco

D'Adamo, Adamo P

Iorio, Annamaria

Sinagra, Gianfranco

Carracedo, Angel

Cummings, Steven R

Nalls, Michael A

Jula, Antti

Kontula, Kimmo K

Marjamaa, Annukka

Oikarinen, Lasse

Perola, Markus

Porthan, Kimmo

Erbel, Raimund

Hoffmann, Per

Jöckel, Karl-Heinz

Kälsch, Hagen

Nöthen, Markus M

den Hoed, Marcel

Loos, Ruth J F

Thelle, Dag S

Gieger, Christian

Meitinger, Thomas

Perz, Siegfried

Peters, Annette

Prucha, Hanna

Sinner, Moritz F

Waldenberger, Melanie

de Boer, Rudolf A

Franke, Lude

van der Vleuten, Pieter A

Beckmann, Britt Maria

Martens, Eimo

Bardai, Abdennasser

Hofman, Nynke

Wilde, Arthur A M

Behr, Elijah R

Dalageorgou, Chrysoula

Giudicessi, John R

Medeiros-Domingo, Argelia

Barc, Julien

Kyndt, Florence

Probst, Vincent

Ghidoni, Alice

Insolia, Roberto

Hamilton, Robert M

Scherer, Stephen W

Brandimarto, Jeffrey

Margulies, Kenneth

Moravec, Christine E

Greco M, Fabiola Del

Fuchsberger, Christian

O'Connell, Jeffrey R

Lee, Wai K

Watt, Graham C M

Campbell, Harry

Wild, Sarah H

El Mokhtari, Nour E

Frey, Norbert

Asselbergs, Folkert W

Mateo Leach, Irene

Navis, Gerjan

van den Berg, Maarten P

van Veldhuisen, Dirk J

Kellis, Manolis

Krijthe, Bouwe P
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Franco, Oscar H
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Hofman, Albert
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Kors, Jan A

Uitterlinden, André G
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Witteman, Jacqueline C M
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Kedenko, Lyudmyla

Lamina, Claudia

Oostra, Ben A

Abecasis, Gonçalo R

Lakatta, Edward G

Mulas, Antonella

Orrú, Marco

Schlessinger, David

Uda, Manuela

Markus, Marcello R P

Völker, Uwe

Snieder, Harold

Spector, Timothy D

Ärnlöv, Johan
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Lind, Lars
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
Sundström, Johan

Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Kivimaki, Mika

Kähönen, Mika

Mononen, Nina

Raitakari, Olli T

Viikari, Jorma S

Adamkova, Vera

Kiechl, Stefan

Brion, Maria

Nicolaides, Andrew N

Paulweber, Bernhard

Haerting, Johannes

Dominiczak, Anna F

Nyberg, Fredrik

Whincup, Peter H

Hingorani, Aroon D

Schott, Jean-Jacques

Bezzina, Connie R

Ingelsson, Erik
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Ferrucci, Luigi

Gasparini, Paolo

Wilson, James F

Rudan, Igor

Franke, Andre

Mühleisen, Thomas W

Pramstaller, Peter P

Lehtimäki, Terho J

Paterson, Andrew D

Parsa, Afshin

Liu, Yongmei

van Duijn, Cornelia M

Siscovick, David S

Gudnason, Vilmundur

Jamshidi, Yalda

Salomaa, Veikko

Felix, Stephan B

Sanna, Serena

Ritchie, Marylyn D

Stricker, Bruno H
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Stefansson, Kari

Boyer, Laurie A

Cappola, Thomas P

Olsen, Jesper V

Lage, Kasper

Schwartz, Peter J

Kääb, Stefan

Chakravarti, Aravinda

Ackerman, Michael J

Pfeufer, Arne

de Bakker, Paul I W

Newton-Cheh, Christopher
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.2014In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, no 8, p. 826-836Article in journal (Refereed)
Abstract [en]
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.
Publisher's full text
17. Recent advances in single-molecule fluorescence microscopy render structural biology dynamic
Bacic, Luka
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.

Sabantsev, Anton
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Deindl, Sebastian
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Recent advances in single-molecule fluorescence microscopy render structural biology dynamic2020In: Current opinion in structural biology, ISSN 0959-440X, E-ISSN 1879-033X, Vol. 65, p. 61-68Article in journal (Refereed)
Abstract [en]
Single-molecule fluorescence microscopy has long been appreciated as a powerful tool to study the structural dynamics that enable biological function of macromolecules. Recent years have witnessed the development of more complex single-molecule fluorescence techniques as well as powerful combinations with structural approaches to obtain mechanistic insights into the workings of various molecular machines and protein complexes. In this review, we highlight these developments that together bring us one step closer to a dynamic understanding of biological processes in atomic details.
Download full text (pdf)
fulltext
Publisher's full text
18. Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adiposity and Bone MassBahl, Aileen
et al.

Pöllänen, Eija

Ismail, Khadeeja

Sipilä, Sarianna

Mikkola, Tuija M

Berglund, Eva C
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Lindqvist, Carl Mårten
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Rantanen, Taina

Kaprio, Jaakko

Kovanen, Vuokko

Ollikainen, Miina
Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adiposity and Bone Mass2015In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 18, no 6, p. 647-661Article in journal (Refereed)
Abstract [en]
The loss of estrogen during menopause causes changes in the female body, with wide-ranging effects on health. Estrogen-containing hormone replacement therapy (HRT) leads to a relief of typical menopausal symptoms, benefits bone and muscle health, and is associated with tissue-specific gene expression profiles. As gene expression is controlled by epigenetic factors (including DNA methylation), many of which are environmentally sensitive, it is plausible that at least part of the HRT-associated gene expression is due to changes in DNA methylation profile. We investigated genome-wide DNA methylation and gene expression patterns of white blood cells (WBCs) and their associations with body composition, including muscle and bone measures of monozygotic (MZ) female twin pairs discordant for HRT. We identified 7,855 nominally significant differentially methylated regions (DMRs) associated with 4,044 genes. Of the genes with DMRs, five (ACBA1, CCL5, FASLG, PPP2R2B, and UHRF1) were also differentially expressed. All have been previously associated with HRT or estrogenic regulation, but not with HRT-associated DNA methylation. All five genes were associated with bone mineral content (BMC), and ABCA1, FASLG, and UHRF1 were also associated with body adiposity. Our study is the first to show that HRT associates with genome-wide DNA methylation alterations in WBCs. Moreover, we show that five differentially expressed genes with DMRs associate with clinical measures, including body fat percentage, lean body mass, bone mass, and blood lipids. Our results indicate that at least part of the known beneficial HRT effects on body composition and bone mass may be regulated by DNA methylation associated alterations in gene expression in circulating WBCs.
Publisher's full text
19. Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain
Bazov, Igor
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.

Sarkisyan, Daniil
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Kononenko, Olga
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Watanabe, Hiroyuki
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Taqi, Malik Mumtaz
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Faculty of Medicine, NORMENT, University of Oslo, Oslo, Norway.
Stålhandske, Lada
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Verbeek, Dineke S
Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Mulder, Jan
Department of Neuroscience, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.
Rajkowska, Grazyna
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Sheedy, Donna
Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney NSW, Australia.
Kril, Jillian
Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney NSW, Australia.
Sun, Xueguang
Zymo Research Corporation, 17062 Murphy Avenue, Irvine, CA, USA; Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.
Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Yakovleva, Tatiana
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Bakalkin, Georgy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain2018In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 28, no 9, p. 3129-3142Article in journal (Refereed)
Abstract [en]
Molecular mechanisms that define patterns of neuropeptide expression are essential for the formation and rewiring of neural circuits. The prodynorphin gene (PDYN) gives rise to dynorphin opioid peptides mediating depression and substance dependence. We here demonstrated that PDYN is expressed in neurons in human dorsolateral prefrontal cortex (dlPFC), and identified neuronal differentially methylated region in PDYN locus framed by CCCTC-binding factor binding sites. A short, nucleosome size human-specific promoter CpG island (CGI), a core of this region may serve as a regulatory module, which is hypomethylated in neurons, enriched in 5-hydroxymethylcytosine, and targeted by USF2, a methylation-sensitive E-box transcription factor (TF). USF2 activates PDYN transcription in model systems, and binds to nonmethylated CGI in dlPFC. USF2 and PDYN expression is correlated, and USF2 and PDYN proteins are co-localized in dlPFC. Segregation of activatory TF and repressive CGI methylation may ensure contrasting PDYN expression in neurons and glia in human brain.
Publisher's full text
20. The fat mass and obesity-associated gene (FTO) is linked to higher plasma levels of the hunger hormone ghrelin and lower serum levels of the satiety hormone leptin in older adults
Benedict, Christian
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.

Axelsson, Tomas
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Söderberg, Stefan

Larsson, Anders
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Ingelsson, Erik
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Lind, Lars
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
Schiöth, Helgi B
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
The fat mass and obesity-associated gene (FTO) is linked to higher plasma levels of the hunger hormone ghrelin and lower serum levels of the satiety hormone leptin in older adults2014In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 63, no 11, p. 3955-3959Article in journal (Refereed)
Abstract [en]
The mechanisms through which common polymorphisms in the fat mass and obesity-associated gene (FTO) drive the development of obesity in humans are poorly understood. By using C: ross-sectional data from 985 elderly (50% females) who participated at age 70 years in the Prospective Investigation of the Vasculature in Uppsala Seniors, circulating levels of ghrelin and leptin were measured after an overnight fast. In addition, subjects were genotyped for FTO rs17817449 (AA, n=345 (35%); AC/CA, n=481 (48.8%); CC, n=159 (16.1%). Linear regression analyses controlling for sex, self-reported physical activity level, fasting plasma glucose, and body mass index were utilized. A positive relationship between the number of FTO C risk alleles and plasma ghrelin levels was found (P=0.005; relative plasma ghrelin difference between CC and AA carriers = ∼9%). In contrast, serum levels of the satiety enhancing hormone leptin were inversely linked to the number of FTO C risk alleles (P=0.001; relative serum leptin difference between CC and AA carriers = ∼11%). These associations were also found when controlling for waist circumference. The present findings suggest that FTO may facilitate weight gain in humans by shifting the endocrine balance from the satiety hormone leptin toward the hunger promoting hormone ghrelin.
Publisher's full text
21. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosusBentham, James
et al.

Morris, David L

Cunninghame Graham, Deborah S

Pinder, Christopher L

Tombleson, Philip

Behrens, Timothy W

Martín, Javier

Fairfax, Benjamin P

Knight, Julian C

Chen, Lingyan

Replogle, Joseph

Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Rönnblom, Lars
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Graham, Robert R

Wither, Joan E

Rioux, John D

Alarcón-Riquelme, Marta E

Vyse, Timothy J
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus2015In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 47, no 12, p. 1457-1464Article in journal (Refereed)
Abstract [en]
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous genome-wide association studies (GWAS) had modest sample sizes, reducing their scope and reliability. Our study comprised 7,219 cases and 15,991 controls of European ancestry, constituting a new GWAS, a meta-analysis with a published GWAS and a replication study. We have mapped 43 susceptibility loci, including ten new associations. Assisted by dense genome coverage, imputation provided evidence for missense variants underpinning associations in eight genes. Other likely causal genes were established by examining associated alleles for cis-acting eQTL effects in a range of ex vivo immune cells. We found an over-representation (n = 16) of transcription factors among SLE susceptibility genes. This finding supports the view that aberrantly regulated gene expression networks in multiple cell types in both the innate and adaptive immune response contribute to the risk of developing SLE.
Publisher's full text
22. IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases
Berggren, Olof
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.

Alexsson, Andrei
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Morris, David
King’s College London School of Medicine, Guy’s Hospital, London.
Tandre, Karolina
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Weber, Gert
Free University of Berlin.
Vyse, Timothy
King’s College London School of Medicine, Guy’s Hospital, London.
Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Rönnblom, Lars
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Eloranta, Maija-Leena
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases2015In: Human Molecular Genetics, ISSN 0964-6906, E-ISSN 1460-2083, Vol. 24, no 12, p. 3571-3581Article in journal (Refereed)
Abstract [en]
The type I interferon (IFN) system is persistently activated in systemic lupus erythematosus (SLE) and many other systemic autoimmune diseases. Studies have shown an association between SLE and several gene variants within the type I IFN system. We investigated whether single nucleotide polymorphisms (SNPs) associated with SLE and other autoimmune diseases affect the IFN-α production in healthy individuals. Plasmacytoid dendritic cells (pDCs), B and NK cells were isolated from peripheral blood of healthy individuals and stimulated with RNA-containing immune complexes (IC), herpes simplex virus (HSV) or the oligonucleotide ODN2216. IFN-α production by pDCs alone or in cocultures with B or NK cells was measured by an immunoassay. All donors were genotyped with the 200K ImmunoChip and a 5bp CGGGG length polymorphism in the IFN regulatory factor 5 gene (IRF5) was genotyped by PCR. We found associations between IFN-α production and 18-86 SNPs (p ≤ 0.001), depending on the combination of the stimulated cell types. However, only three of these associated SNPs were shared between the cell type combinations. Several SNPs showed novel associations to the type I IFN system among all the associated SNPs, while some loci have been described earlier for their association with SLE. Furthermore, we found that the SLE-risk variant of the IRF5 CGGGG-indel was associated with lower IFN-α production. We conclude that the genetic variants affecting the IFN-α production highlight the intricate regulation of the type I IFN system and the importance of understanding the mechanisms behind the dysregulated type I IFN system in SLE.
Publisher's full text
23. Next generation sequencing technologies and applications for human Genetic History and Forensics
Berglund, Eva C
et al.

Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.

Kiialainen, Anna
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
Syvänen, Ann-Christine
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLif

Logo: to the web site of Uppsala University

Advanced search

Limit the search further

Limit the search further

Chen, Doris

Ahlford, Annika

Schnorrer, Frank

Kalchhauser, Irene

Fellner, Michaela

Viràgh, Erika

Kiss, Istvàn

Syvänen, Ann-Christine

Dickson, Barry J

Abstract [en]

Keywords

National Category

Identifiers

Schnorrer, Frank

Ahlford, Annika

Chen, Doris

Milani, Lili

Syvänen, Ann-Christine

Abstract [en]

National Category

Identifiers

Ahlford, Annika

Kjeldsen, Bastian

Reimers, Jakob

Lundmark, Anders

Romani, Massimo

Wolff, Anders

Syvänen, Ann-Christine

Brivio, Monica

Abstract [en]

National Category

Identifiers